A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus

J. D. Chen, J. F. Hejtmancik, G. Romeo, M. Lindlof, C. Boehm, C. T. Caskey, W. Kress, K. H. Fischbeck, M. Dreier, S. Serravalle, T. Grimm, H. Kaariainen, M. Ferrari, E. Pfendner, G. Meng, A. de la Chapelle, M. A. Melis, B. Muller, A. G. MacKinlay, C. R. MullerM. J. Denton

Research output: Contribution to journalArticle

Abstract

Linkage analysis of five marker loci in and around the Duchenne muscular dystrophy (DMD) locus, DXS84, DXS206, DXS164, DXS270, and DXS28, was conducted with 499 families. Overall, the best multipoint distances were found to be DXS84-37 ± 0.6 cM-DXS206-1.0 ± 0.4 cM-DXS164-1.9 ± 0.6 cM-DXS270-12.0 ± 1.1 cM-DXS28. A comparison of this linkage map with the established physical map suggests the presence of hot spots for recombination in the DMD locus.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalGenomics
Volume4
Issue number1
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Genetics

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    Chen, J. D., Hejtmancik, J. F., Romeo, G., Lindlof, M., Boehm, C., Caskey, C. T., Kress, W., Fischbeck, K. H., Dreier, M., Serravalle, S., Grimm, T., Kaariainen, H., Ferrari, M., Pfendner, E., Meng, G., de la Chapelle, A., Melis, M. A., Muller, B., MacKinlay, A. G., ... Denton, M. J. (1989). A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus. Genomics, 4(1), 105-109. https://doi.org/10.1016/0888-7543(89)90322-4