TY - JOUR
T1 - A genetic linkage study of schizophrenia to chromosome 5 markers in a Northern Italian population
AU - Macciardi, F.
AU - Kennedy, J. L.
AU - Ruocco, L.
AU - Giuffra, L.
AU - Carrera, P.
AU - Marino, C.
AU - Rinaldi, V.
AU - Smeraldi, E.
AU - Ferrari, M.
PY - 1992/4/1
Y1 - 1992/4/1
N2 - Some recent finding report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigress segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
AB - Some recent finding report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigress segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
UR - http://www.scopus.com/inward/record.url?scp=0026720514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026720514&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(92)90282-5
DO - 10.1016/0006-3223(92)90282-5
M3 - Article
C2 - 1599988
AN - SCOPUS:0026720514
VL - 31
SP - 720
EP - 728
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 7
ER -