A genetic linkage study of schizophrenia to chromosome 5 markers in a Northern Italian population

F. Macciardi, J. L. Kennedy, L. Ruocco, L. Giuffra, P. Carrera, C. Marino, V. Rinaldi, E. Smeraldi, M. Ferrari

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Abstract

Some recent finding report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigress segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.

Original languageEnglish
Pages (from-to)720-728
Number of pages9
JournalBiological Psychiatry
Volume31
Issue number7
DOIs
Publication statusPublished - Apr 1 1992

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ASJC Scopus subject areas

  • Biological Psychiatry

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