A genetic study of neostriatal cholinergic neurones in C57BL/6 and DBA/2 mice.

M. C. Altavista, S. Gozzo, C. Iacopino, A. Albanese

Research output: Contribution to journalArticle


In the present study Butcher's pharmaco-histochemical technique for acetylcholinesterase has been employed for a morphometrical analysis of striatal cholinergic neurones in crossbred C57BL/6 x DBA/2 F1 mice. The general organization of neostriatal cholinergic systems in hybrid mice was similar to that of parent strains. However, as shown by morphometry, the size of neostriatum in hybrids was larger than that of both parental strains, and the density of striatal cholinergic neurones was significantly lower than that of DBA/2 mice, being close to that of the C57BL/6 strain. The present data indicate that a reduced number of striatal cholinergic neurones is inherited as a dominant trait by these hybrid mice.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalFunctional Neurology
Issue number3
Publication statusPublished - Jul 1987


ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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