A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug

Neda M Bogari, Ashwag Aljohani, Amr A Amin, Faisal A Al-Allaf, Anas Dannoun, Mohiuddin M Taher, Atalla Elsayed, Dareen Ibrahim Rednah, Osama Elkhatee, Massimo Porqueddu, Francesco Alamanni, Soud Abdulraof A Khogeer, Ahmed Fawzy

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Elevated plasma triglycerides (TGs) are widely used as a major cardiovascular risk predictor and are thought to play an important role in the progression of coronary heart disease (CHD). It has been demonstrated that lipid lowering was associated with lower mortality in patients with CHD. The present study therefore aimed to investigate the consequences of the genetic variant c.553G > T (rs2075291) in apolipoprotein A5 gene to determination of triglycerides levels in CAD patients receiving, atorvastatin, lipid lowering drug.

METHODS: We here report that a recently identified genetic variant, c.553G > T in the APOA5 gene which causes a substitution of a cysteine for a glycine residue at amino acid residue 185(G185C) is also associated with increased TG levels. To investigate theses effects, a case-control study compressing 608 subjects from the same area was performed.

RESULTS: TG levels in T allele patients were significantly lower than the control GT allele patient (χ2 = 2.382E2a, P-value < 0.001). Overall, patients carrying T allele showed lower levels of TG than patients carrying GG allele. The homozygous patient for the T allele presented normal cholesterol levels of 134 mg/dl, and the levels in GG patients ranged from 25 to 340 mg/dl (P-value < 0.001). In summary, we demonstrated that the presence of c.553G > T variant (rs2075291); in APOA5 gene increases human plasma TG levels.

CONCLUSION: Nevertheless, T allele is found to reduce TG levels in CAD patients who are on the cholesterol medication, atorvastatin. Thus, c.553G > T variant can be considered as a significant predicator of hypertriglyceridemia. In addition, it could be used as a hallmark for the diagnosis and prognosis of CAD.

Original languageEnglish
Pages (from-to)2
JournalBMC Cardiovascular Disorders
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 3 2019

Keywords

  • Adult
  • Aged
  • Apolipoprotein A-V/genetics
  • Atorvastatin/therapeutic use
  • Biomarkers/blood
  • Case-Control Studies
  • Coronary Artery Disease/blood
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
  • Hypertriglyceridemia/blood
  • Male
  • Middle Aged
  • Phenotype
  • Treatment Outcome
  • Triglycerides/blood
  • Young Adult

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    Bogari, N. M., Aljohani, A., Amin, A. A., Al-Allaf, F. A., Dannoun, A., Taher, M. M., Elsayed, A., Rednah, D. I., Elkhatee, O., Porqueddu, M., Alamanni, F., Khogeer, S. A. A., & Fawzy, A. (2019). A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug. BMC Cardiovascular Disorders, 19(1), 2. https://doi.org/10.1186/s12872-018-0965-3