A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Daniela Beghelli; Robertina Giacconi; Eugenio Mocchegiani; Catia Cipriano; Marco Malavolta; Carlo Renieri

doi:10.1016/j.tvjl.2010.12.028

A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Daniela Beghelli, Robertina Giacconi, Eugenio Mocchegiani, Catia Cipriano, Marco Malavolta, Carlo Renieri

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.

Original language	English
Journal	Veterinary Journal
Volume	190
Issue number	2
DOIs	https://doi.org/10.1016/j.tvjl.2010.12.028
Publication status	Published - Nov 2011

Keywords

Copper:zinc ratio
Equine
Interleukin 6
Single nucleotide polymorphism

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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abstract = "The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.",

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AU - Beghelli, Daniela

AU - Giacconi, Robertina

AU - Mocchegiani, Eugenio

AU - Cipriano, Catia

AU - Malavolta, Marco

AU - Renieri, Carlo

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KW - Interleukin 6

KW - Single nucleotide polymorphism

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A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Abstract

Keywords

ASJC Scopus subject areas

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