A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Daniela Beghelli; Robertina Giacconi; Eugenio Mocchegiani; Catia Cipriano; Marco Malavolta; Carlo Renieri

doi:10.1016/j.tvjl.2010.12.028

A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Daniela Beghelli, Robertina Giacconi, Eugenio Mocchegiani, Catia Cipriano, Marco Malavolta, Carlo Renieri

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.

Original language	English
Journal	Veterinary Journal
Volume	190
Issue number	2
DOIs	https://doi.org/10.1016/j.tvjl.2010.12.028
Publication status	Published - Nov 2011

Keywords

Copper:zinc ratio
Equine
Interleukin 6
Single nucleotide polymorphism

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

Access to Document

10.1016/j.tvjl.2010.12.028

Cite this

@article{2ecba1d3b8184070a8015a231c0dbcce,

title = "A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio",

abstract = "The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.",

keywords = "Copper:zinc ratio, Equine, Interleukin 6, Single nucleotide polymorphism",

author = "Daniela Beghelli and Robertina Giacconi and Eugenio Mocchegiani and Catia Cipriano and Marco Malavolta and Carlo Renieri",

year = "2011",

month = nov,

doi = "10.1016/j.tvjl.2010.12.028",

language = "English",

volume = "190",

journal = "Veterinary Journal",

issn = "1090-0233",

publisher = "Bailliere Tindall Ltd",

number = "2",

}

TY - JOUR

T1 - A genetic variant near the equine interleukin 6 gene associated with copper

T2 - zinc ratio

AU - Beghelli, Daniela

AU - Giacconi, Robertina

AU - Mocchegiani, Eugenio

AU - Cipriano, Catia

AU - Malavolta, Marco

AU - Renieri, Carlo

PY - 2011/11

Y1 - 2011/11

N2 - The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.

AB - The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.

KW - Copper:zinc ratio

KW - Equine

KW - Interleukin 6

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=82855175316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82855175316&partnerID=8YFLogxK

U2 - 10.1016/j.tvjl.2010.12.028

DO - 10.1016/j.tvjl.2010.12.028

M3 - Article

C2 - 21330167

AN - SCOPUS:82855175316

VL - 190

JO - Veterinary Journal

JF - Veterinary Journal

SN - 1090-0233

IS - 2

ER -

A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this