A genetic variant near the equine interleukin 6 gene associated with copper: zinc ratio

Daniela Beghelli, Robertina Giacconi, Eugenio Mocchegiani, Catia Cipriano, Marco Malavolta, Carlo Renieri

Research output: Contribution to journalArticle

Abstract

The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise.

Original languageEnglish
JournalVeterinary Journal
Volume190
Issue number2
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Copper:zinc ratio
  • Equine
  • Interleukin 6
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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