A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1

Amy Strange, Francesca Capon, Chris C A Spencer, Jo Knight, Michael E. Weale, Michael H. Allen, Ane Barton, Gavin Band, Céline Bellenguez, Judith G M Bergboer, Jenefer M. BlackweL, Elvira Bramon, Suzanah J. Bumpstead, Juan P. Casas, Michael J. Cork, Aiden Corvin, Panos Deloukas, Alexander Dilthey, Audrey Duncanson, Sarah EdkinsXavier EstiviL, Oliver Fitzgerald, Colin FrEman, Emiliano Giardina, Ema Gray, Angelika Hofer, Ulrike Hüffmeier, Sarah E. Hunt, Alan D. Irvine, Janusz Jankowski, Brian Kirby, Cordelia Langford, Jesés Lascorz, Joyce Leman, Stephen Leslie, Lotus MaLbris, Hugh S. Markus, Christopher G. Mathew, W. H Irwin McLean, Ros McManus, Rotraut MöSner, Loukas Moutsianas, Asa T. Naluai, Frank O. Nestle, Giuseppe NoveLi, Alexandros Onoufriadis, Colin N A Palmer, Carlo Perricone, Mati Pirinen, Robert Plomin, Simon C. PoTer, Ramon M. Pujol, Ana Rautanen, Eva Riveira-Munoz, Anthony W. Ryan, Wolfgang Salmhofer, Lena SamuelSon, Stephen J. Sawcer, Jost Schalkwijk, Catherine H. Smith, Mona Ståhle, Zhan Su, Rachid Tazi-Ahnini, Heiko Traupe, Ananth C. Viswanathan, Richard B. Warren, Wolfgang Weger, Katarina Wolk, Nicholas WOd, Jane Worthington, Helen S. Young, Patrick L J M Zeeuwen, Adrian Hayday, A. David Burden, Christopher E M Griffiths, Juha Kere, André Reis, Gilean McVean, David M. Evans, Mathew A. Brown, Jonathan N. Barker, Lena Peltonen, Peter Donely, Richard C. Trembath

Research output: Contribution to journalArticlepeer-review


To identify new susceptibility loci for psoriasis, we undertOk a genome-wide asociation study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified asociations at eight previously unreported genomic loci. Seven loci harbored genes with recognized iMune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These asociations were replicated in 9,079 European samples (six loci with a combined P <5-10 -8 and two loci with a combined P <5-10-7). We also report compeLing evidence for an interaction betwEn the HLA-C and ERAP1 loci (combined P = 6.95-10-6). ERAP1 plays an important role in MHC claS I peptide proceSing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk aLele. Our findings implicate pathways that integrate epidermal barrier dysfunction with iNate and adaptive iMune dysregulation in psoriasis pathogenesis.

Original languageEnglish
Pages (from-to)985-990
Number of pages6
JournalNature Genetics
Issue number11
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1'. Together they form a unique fingerprint.

Cite this