A genome-wide association study in progressive multiple sclerosis

Filippo Martinelli-Boneschi, Federica Esposito, Paola Brambilla, Eva Lindström, Giovanni Lavorgna, Jim Stankovich, Mariaemma Rodegher, Ruggero Capra, Angelo Ghezzi, Gabriella Coniglio, Bruno Colombo, Melissa Sorosina, Vittorio Martinelli, David Booth, Annette Bang Oturai, Graeme Stewart, Hanne F. Harbo, Trevor John Kilpatrick, Jan Hillert, Justin P. RubioHadi Abderrahim, Jerome Wojcik, Giancarlo Comi

Research output: Contribution to journalArticlepeer-review


Background: The role played by genetic factors in influencing the clinical course of multiple sclerosis (MS) is not yet well established.Objective: We aimed to identify genetic variants associated with progressive MS (PrMS).Methods: We conducted a genome-wide association study (GWAS) in 197 patients with PrMS and 234 controls of Italian origin. We tested the top 20 single nucleotide polymorphisms (SNPs) with suggestive evidence of association (p-value

Original languageEnglish
Pages (from-to)1384-1394
Number of pages11
JournalMultiple Sclerosis Journal
Issue number10
Publication statusPublished - 2012


  • association studies in genetics
  • genome-wide association study
  • multiple sclerosis
  • primary progressive
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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