A genotype-specific baseline score predicts post-treatment response to peginterferon alfa-2A in hepatitis B e antigen-negative chronic hepatitis B

Pietro Lampertico, Diethelm Messinger, Markus Cornberg, Maurizia Brunetto, Jörg Petersen, Patrick Kennedy, Tarik Asselah, Vivien Rothe, Antonietta Caputo, Georgios Bakalos, Vedran Pavlovic, George V. Papatheodoridis

Research output: Contribution to journalArticle

Abstract

Background Peginterferon alfa-2a induces durable responses in some hepatitis B e antigen-negative patients, but robust pretreatment predictors are not available to identify likely responders. In this study we aimed to develop genotype-specific baseline scoring systems to predict response. Methods Data from 323 hepatitis B e antigen-negative peginterferon alfa-2a recipients from three studies were analyzed. Scoring systems were developed using generalized additive models and multiple logistic regression analysis. Response was defined as hepatitis B virus DNA <2000 IU/mL alone (virological response) or in combination with alanine aminotransferase normalization (combined response) 48 weeks post-treatment. Results Points were assigned to genotype B/C patients for: age, alanine aminotransferase ratio, genotype B or C, and hepatitis B surface antigen level; and to genotype D patients for: age, hepatitis B surface antigen level and hepatitis B virus DNA level. Higher total scores (range 0-5 for B/C; 0-3 for D) indicated a higher likelihood of response. Among genotype B/C patients with scores of 0-1, 2 and ≥3, respectively, virological response rates were 16.7%, 25.8% and 70.2%, and combined response rates were 12.5%, 21.0% and 57.4%. Among genotype D patients with scores of 0-1, 2 and 3, respectively, virological response rates were 10.1%, 28.0% and 50.0%, and combined response rates were 7.8%, 28.0% and 33.3%. Conclusion Genotype-specific baseline scoring systems can identify hepatitis B e antigen-negative patients with low or high likelihood of achieving sustained responses to peginterferon alfa-2a.

Original languageEnglish
Pages (from-to)712-721
Number of pages10
JournalAnnals of Gastroenterology
Volume31
Issue number6
DOIs
Publication statusPublished - Oct 20 2018

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Keywords

  • HBeAg
  • HBsAg
  • Predictors
  • Treatment
  • Virological response

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lampertico, P., Messinger, D., Cornberg, M., Brunetto, M., Petersen, J., Kennedy, P., Asselah, T., Rothe, V., Caputo, A., Bakalos, G., Pavlovic, V., & Papatheodoridis, G. V. (2018). A genotype-specific baseline score predicts post-treatment response to peginterferon alfa-2A in hepatitis B e antigen-negative chronic hepatitis B. Annals of Gastroenterology, 31(6), 712-721. https://doi.org/10.20524/aog.2018.0300