A global risk approach to identify patients with left main or 3-vessel disease who could safely and efficaciously be treated with percutaneous coronary intervention: The SYNTAX trial at 3 years

Patrick W. Serruys, Vasim Farooq, Pascal Vranckx, Chrysafios Girasis, Salvatore Brugaletta, Hector M. Garcia-Garcia, David R. Holmes, Arie Pieter Kappetein, Michael J. Mack, Ted Feldman, Marie Claude Morice, Elisabeth Ståhle, Stefan James, Antonio Colombo, Peggy Pereda, Jian Huang, Marie Angèle Morel, Gerrit Anne Van Es, Keith D. Dawkins, Friedrich W. MohrEwout W. Steyerberg

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to assess the additional value of the Global Risk - a combination of the SYNTAX Score (SXscore) and additive EuroSCORE - in the identification of a low-risk population, who could safely and efficaciously be treated with coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI). Background: PCI is increasingly acceptable in appropriately selected patients with left main stem or 3-vessel coronary artery disease. Methods: Within the SYNTAX Trial (Synergy between PCI with TAXUS and Cardiac Surgery Trial), all-cause death and major adverse cardiac and cerebrovascular events (MACCE) were analyzed at 36 months in low (GRC LOW) to high Global Risk groups, with Kaplan-Meier, log-rank, and Cox regression analyses. Results: Within the randomized left main stem population (n = 701), comparisons between GRC LOW groups demonstrated a significantly lower mortality with PCI compared with CABG (CABG: 7.5%, PCI: 1.2%, hazard ratio [HR]: 0.16, 95% confidence interval [CI]: 0.03 to 0.70, p = 0.0054) and a trend toward reduced MACCE (CABG: 23.1%, PCI: 15.8%, HR: 0.64, 95% CI: 0.39 to 1.07, p = 0.088). Similar analyses within the randomized 3-vessel disease population (n = 1,088) demonstrated no statistically significant differences in mortality (CABG: 5.2%, PCI: 5.8%, HR: 1.14, 95% CI: 0.57 to 2.30, p = 0.71) or MACCE (CABG: 19.0%, PCI: 24.7%, HR: 1.35, 95% CI: 0.95 to 1.92, p = 0.10). Risk-model performance and reclassification analyses demonstrated that the EuroSCORE--with the added incremental benefit of the SXscore to form the Global Risk--enhanced the risk stratification of all PCI patients. Conclusions: In comparison with the SXscore, the Global Risk, with a simple treatment algorithm, substantially enhances the identification of low-risk patients who could safely and efficaciously be treated with CABG or PCI.

Original languageEnglish
Pages (from-to)606-617
Number of pages12
JournalJACC: Cardiovascular Interventions
Volume5
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • 3-vessel disease
  • Global Risk
  • left main disease
  • SYNTAX Score

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Serruys, P. W., Farooq, V., Vranckx, P., Girasis, C., Brugaletta, S., Garcia-Garcia, H. M., Holmes, D. R., Kappetein, A. P., Mack, M. J., Feldman, T., Morice, M. C., Ståhle, E., James, S., Colombo, A., Pereda, P., Huang, J., Morel, M. A., Van Es, G. A., Dawkins, K. D., ... Steyerberg, E. W. (2012). A global risk approach to identify patients with left main or 3-vessel disease who could safely and efficaciously be treated with percutaneous coronary intervention: The SYNTAX trial at 3 years. JACC: Cardiovascular Interventions, 5(6), 606-617. https://doi.org/10.1016/j.jcin.2012.03.016