Abstract
In patients with osteosarcoma several causative factors are implicated in the occurrence of osteoporosis, such as no weight-bearing, pre- and post-surgical immobilization, and neoadjuvant and adjuvant chemotherapy. Nevertheless, osteoporotic fractures are a rare complication in young patients. We report the case of a spontaneous greenstick fracture of the distal tibia occurring during adjuvant chemotherapy in a 12-year-old Caucasian girl. Among the various drugs, the main role of methotrexate was investigated. A review of the literature is also presented along with a discussion about the role of preventive agents able to reduce the occurrence of osteopenia and/or osteoporosis following cancer treatment.
Original language | English |
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Pages (from-to) | 131-135 |
Number of pages | 5 |
Journal | Journal of Biological Regulators and Homeostatic Agents |
Volume | 25 |
Issue number | 1 |
Publication status | Published - Jan 2011 |
Keywords
- Chemotherapy-induced osteoporosis
- Childhood osteoporosis fractures
- Juvenile osteoporosis
- Methotrexate toxicity
ASJC Scopus subject areas
- Oncology
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)
- Immunology and Allergy
- Immunology
- Endocrinology
- Physiology
- Cancer Research