A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events?

Carmine Zoccali; G. Chichierchia; U. Prencipe; C. Nuzzo; V. Anelli; V. Ferraresi

A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events?

Carmine Zoccali, G. Chichierchia, U. Prencipe, C. Nuzzo, V. Anelli, V. Ferraresi

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

In patients with osteosarcoma several causative factors are implicated in the occurrence of osteoporosis, such as no weight-bearing, pre- and post-surgical immobilization, and neoadjuvant and adjuvant chemotherapy. Nevertheless, osteoporotic fractures are a rare complication in young patients. We report the case of a spontaneous greenstick fracture of the distal tibia occurring during adjuvant chemotherapy in a 12-year-old Caucasian girl. Among the various drugs, the main role of methotrexate was investigated. A review of the literature is also presented along with a discussion about the role of preventive agents able to reduce the occurrence of osteopenia and/or osteoporosis following cancer treatment.

Original language	English
Pages (from-to)	131-135
Number of pages	5
Journal	Journal of Biological Regulators and Homeostatic Agents
Volume	25
Issue number	1
Publication status	Published - Jan 2011

Keywords

Chemotherapy-induced osteoporosis
Childhood osteoporosis fractures
Juvenile osteoporosis
Methotrexate toxicity

ASJC Scopus subject areas

Oncology
Endocrinology, Diabetes and Metabolism
Physiology (medical)
Immunology and Allergy
Immunology
Endocrinology
Physiology
Cancer Research

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Zoccali, C., Chichierchia, G., Prencipe, U., Nuzzo, C., Anelli, V., & Ferraresi, V. (2011). A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events? Journal of Biological Regulators and Homeostatic Agents, 25(1), 131-135.

A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee : Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events? / Zoccali, Carmine; Chichierchia, G.; Prencipe, U.; Nuzzo, C.; Anelli, V.; Ferraresi, V.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 25, No. 1, 01.2011, p. 131-135.

Research output: Contribution to journal › Article › peer-review

Zoccali, C, Chichierchia, G, Prencipe, U, Nuzzo, C, Anelli, V & Ferraresi, V 2011, 'A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events?', Journal of Biological Regulators and Homeostatic Agents, vol. 25, no. 1, pp. 131-135.

Zoccali C, Chichierchia G, Prencipe U, Nuzzo C, Anelli V, Ferraresi V. A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events? Journal of Biological Regulators and Homeostatic Agents. 2011 Jan;25(1):131-135.

Zoccali, Carmine ; Chichierchia, G. ; Prencipe, U. ; Nuzzo, C. ; Anelli, V. ; Ferraresi, V. / A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee : Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events?. In: Journal of Biological Regulators and Homeostatic Agents. 2011 ; Vol. 25, No. 1. pp. 131-135.

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abstract = "In patients with osteosarcoma several causative factors are implicated in the occurrence of osteoporosis, such as no weight-bearing, pre- and post-surgical immobilization, and neoadjuvant and adjuvant chemotherapy. Nevertheless, osteoporotic fractures are a rare complication in young patients. We report the case of a spontaneous greenstick fracture of the distal tibia occurring during adjuvant chemotherapy in a 12-year-old Caucasian girl. Among the various drugs, the main role of methotrexate was investigated. A review of the literature is also presented along with a discussion about the role of preventive agents able to reduce the occurrence of osteopenia and/or osteoporosis following cancer treatment.",

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A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: Does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events?

Abstract

Keywords

ASJC Scopus subject areas

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