A guide to PIN1 function and mutations across cancers

Maguie El Boustani, Lucia De Stefano, Isabella Caligiuri, Nayla Mouawad, Carlotta Granchi, Vincenzo Canzonieri, Tiziano Tuccinardi, Antonio Giordano, Flavio Rizzolio

Research output: Contribution to journalArticle

Abstract

PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review the role of PIN1 in cancer and the regulation of PIN1 expression, and catalog the single nucleotide polymorphisms, and mutations in PIN1 gene associated with cancer. In addition, we provide a 3D model of the protein to localize the mutated residues.

Original languageEnglish
Article number1477
Number of pages10
JournalFrontiers in Pharmacology
Volume9
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • 3D modeling
  • Cancer
  • Mutations
  • PIN1
  • SNP

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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