A heterogeneous dose distribution in simultaneous integrated boost: The role of the clonogenic cell density on the tumor control probability

L. Strigari, M. D'Andrea, A. Abate, M. Benassi

Research output: Contribution to journalArticlepeer-review

Abstract

IMRT with inverse planning allows simultaneous integrated boost strategies that exploit the heterogeneous dose distribution within the planning target volumes (PTVs). In this scenario, the location of cold spots within the target becomes a crucial issue and has to be related to the distribution of the clonogenic cell density (CCD). The main aim of this work is to provide the means to calculate the optimal prescription dose in a relative inhomogeneous dose distribution. To achieve this, the prescription dose has to be assigned to obtain the same tumor control probability (TCP) as the ideal homogeneous distribution, taking into account different CCDs in different PTVs (i.e. visible and subclinical regions). An adapted formulation of the linear-quadratic model, within the F-factor formalism, has been derived to preserve a chosen TCP value for the whole target volume. The F-factor has been investigated to show its potential applications in clinical practice.

Original languageEnglish
Pages (from-to)5257-5273
Number of pages17
JournalPhysics in Medicine and Biology
Volume53
Issue number19
DOIs
Publication statusPublished - Oct 7 2008

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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