A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome

Viola Alesi, Sara Loddo, Federica Calì, Valeria Orlando, Silvia Genovese, Daniele Ferretti, Chiara Calacci, Giusy Calvieri, Roberto Falasca, Lucia Ulgheri, Fabrizio Drago, Bruno Dallapiccola, Anwar Baban, Antonio Novelli

Research output: Contribution to journalArticle

Abstract

Only a few individuals with 12q15 deletion have been described, presenting with a disorder characterized by learning disability, developmental delay, nasal speech, and hypothyroidism. The smallest region of overlap for this syndrome was included in a genomic segment spanning CNOT2, KCNMB4, and PTPRB genes. We report on an additional patient harboring a 12q15 microdeletion encompassing only part of CNOT2 gene, presenting with a spectrum of clinical features overlapping the 12q15 deletion syndrome phenotype. We propose CNOT2 as the phenocritical gene for 12q15 deletion syndrome and its haploinsufficiency being associated with an autosomal dominant disorder, presenting with developmental delay, hypotonia, feeding problems, learning difficulties, nasal speech, skeletal anomalies, and facial dysmorphisms.

Original languageEnglish
JournalAmerican Journal of Medical Genetics, Part A
DOIs
Publication statusE-pub ahead of print - May 30 2019

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Phenotype
Nose
Language Development Disorders
Haploinsufficiency
Muscle Hypotonia
Learning Disorders
Gene Deletion
Hypothyroidism
Genes
Learning

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A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome. / Alesi, Viola; Loddo, Sara; Calì, Federica; Orlando, Valeria; Genovese, Silvia; Ferretti, Daniele; Calacci, Chiara; Calvieri, Giusy; Falasca, Roberto; Ulgheri, Lucia; Drago, Fabrizio; Dallapiccola, Bruno; Baban, Anwar; Novelli, Antonio.

In: American Journal of Medical Genetics, Part A, 30.05.2019.

Research output: Contribution to journalArticle

Alesi, Viola ; Loddo, Sara ; Calì, Federica ; Orlando, Valeria ; Genovese, Silvia ; Ferretti, Daniele ; Calacci, Chiara ; Calvieri, Giusy ; Falasca, Roberto ; Ulgheri, Lucia ; Drago, Fabrizio ; Dallapiccola, Bruno ; Baban, Anwar ; Novelli, Antonio. / A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome. In: American Journal of Medical Genetics, Part A. 2019.
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AU - Alesi, Viola

AU - Loddo, Sara

AU - Calì, Federica

AU - Orlando, Valeria

AU - Genovese, Silvia

AU - Ferretti, Daniele

AU - Calacci, Chiara

AU - Calvieri, Giusy

AU - Falasca, Roberto

AU - Ulgheri, Lucia

AU - Drago, Fabrizio

AU - Dallapiccola, Bruno

AU - Baban, Anwar

AU - Novelli, Antonio

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AB - Only a few individuals with 12q15 deletion have been described, presenting with a disorder characterized by learning disability, developmental delay, nasal speech, and hypothyroidism. The smallest region of overlap for this syndrome was included in a genomic segment spanning CNOT2, KCNMB4, and PTPRB genes. We report on an additional patient harboring a 12q15 microdeletion encompassing only part of CNOT2 gene, presenting with a spectrum of clinical features overlapping the 12q15 deletion syndrome phenotype. We propose CNOT2 as the phenocritical gene for 12q15 deletion syndrome and its haploinsufficiency being associated with an autosomal dominant disorder, presenting with developmental delay, hypotonia, feeding problems, learning difficulties, nasal speech, skeletal anomalies, and facial dysmorphisms.

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