A high-resolution genetic map of mouse Chromosome 15 encompassing the Dominant megacolon (Dom) locus

A. Puliti, M. O. Prehu, D. Simon-Chazottes, L. Ferkdadji, M. Peuchmaur, M. Goossens, J. L. Guénet

Research output: Contribution to journalArticle

Abstract

Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra- and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.

Original languageEnglish
Pages (from-to)763-768
Number of pages6
JournalMammalian Genome
Volume6
Issue number11
DOIs
Publication statusPublished - Nov 1995

ASJC Scopus subject areas

  • Genetics

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    Puliti, A., Prehu, M. O., Simon-Chazottes, D., Ferkdadji, L., Peuchmaur, M., Goossens, M., & Guénet, J. L. (1995). A high-resolution genetic map of mouse Chromosome 15 encompassing the Dominant megacolon (Dom) locus. Mammalian Genome, 6(11), 763-768. https://doi.org/10.1007/BF00539000