A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

Conrad C. Bleul, Robert C. Fuhlbrigge, Jose M. Casasnovas, Alessandro Aiuti, Timothy A. Springer

Research output: Contribution to journalArticlepeer-review

Abstract

Chemotactic factors are postulated to direct emigration of lymphocytes from the blood stream into sites of inflammation. Members of a family of chemotactic cytokines, termed chemokines, have been shown to attract lymphocytes but efficacy, i.e., the maximal percentage of attracted cells, has been low. We have identified a highly efficacious lymphocyte chemotactic activity in the supernatants of the murine bone marrow stroma cell line MS-5 which attracts 10-fold more lymphocytes in vitro than currently described lymphocyte chemoattractants. Purification of this chemotactic activity revealed identity to stromal cell derived factor 1 (SDF-1). SDF-1 acts on lymphocytes anti monocytes but not neutrophils in vitro and is both a highly efficacious and highly potent mononuclear cell attractant in vivo. In addition. SDF-1 induces intracellular actin polymerization in lymphocytes, a process that is thought to be a prerequisite for cell motility. Since SDF-1 is expressed constitutively in a broad range of tissues it may have a role in immune surveillance and in basis extravasation of lymphocytes and monocytes rather than in inflammation.

Original languageEnglish
Pages (from-to)1101-1109
Number of pages9
JournalJournal of Experimental Medicine
Volume184
Issue number3
Publication statusPublished - Sep 1 1996

ASJC Scopus subject areas

  • Immunology

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