A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

Conrad C. Bleul, Robert C. Fuhlbrigge, Jose M. Casasnovas, Alessandro Aiuti, Timothy A. Springer

Research output: Contribution to journalArticle

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Abstract

Chemotactic factors are postulated to direct emigration of lymphocytes from the blood stream into sites of inflammation. Members of a family of chemotactic cytokines, termed chemokines, have been shown to attract lymphocytes but efficacy, i.e., the maximal percentage of attracted cells, has been low. We have identified a highly efficacious lymphocyte chemotactic activity in the supernatants of the murine bone marrow stroma cell line MS-5 which attracts 10-fold more lymphocytes in vitro than currently described lymphocyte chemoattractants. Purification of this chemotactic activity revealed identity to stromal cell derived factor 1 (SDF-1). SDF-1 acts on lymphocytes anti monocytes but not neutrophils in vitro and is both a highly efficacious and highly potent mononuclear cell attractant in vivo. In addition. SDF-1 induces intracellular actin polymerization in lymphocytes, a process that is thought to be a prerequisite for cell motility. Since SDF-1 is expressed constitutively in a broad range of tissues it may have a role in immune surveillance and in basis extravasation of lymphocytes and monocytes rather than in inflammation.

Original languageEnglish
Pages (from-to)1101-1109
Number of pages9
JournalJournal of Experimental Medicine
Volume184
Issue number3
Publication statusPublished - Sep 1 1996

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Chemokine CXCL12
Chemotactic Factors
Lymphocytes
Chemokines
Monocytes
Inflammation
Emigration and Immigration
Polymerization
Bone Marrow Cells
Cell Movement
Actins
Neutrophils
Cell Line

ASJC Scopus subject areas

  • Immunology

Cite this

Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., & Springer, T. A. (1996). A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). Journal of Experimental Medicine, 184(3), 1101-1109.

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). / Bleul, Conrad C.; Fuhlbrigge, Robert C.; Casasnovas, Jose M.; Aiuti, Alessandro; Springer, Timothy A.

In: Journal of Experimental Medicine, Vol. 184, No. 3, 01.09.1996, p. 1101-1109.

Research output: Contribution to journalArticle

Bleul, CC, Fuhlbrigge, RC, Casasnovas, JM, Aiuti, A & Springer, TA 1996, 'A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)', Journal of Experimental Medicine, vol. 184, no. 3, pp. 1101-1109.
Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). Journal of Experimental Medicine. 1996 Sep 1;184(3):1101-1109.
Bleul, Conrad C. ; Fuhlbrigge, Robert C. ; Casasnovas, Jose M. ; Aiuti, Alessandro ; Springer, Timothy A. / A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). In: Journal of Experimental Medicine. 1996 ; Vol. 184, No. 3. pp. 1101-1109.
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