A homozygous contiguous gene deletion in chromosome 16p13.3 leads to autosomal recessive osteopetrosis in a Jordanian patient

Alessandra Pangrazio, Annalisa Frattini, Roberto Valli, Emanuela Maserati, Lucia Susani, Paolo Vezzoni, Anna Villa, Waleed Al-Herz, Cristina Sobacchi

Research output: Contribution to journalArticle

Abstract

Human malignant autosomal recessive osteopetrosis (ARO) is a genetically heterogeneous disorder caused by reduced bone resorption by osteoclasts. Mutations in the CLCN7 gene are responsible not only for a substantial portion of ARO patients but also for other forms of osteopetrosis characterized by different severity and inheritance. The lack of a clear genotype/phenotype correlation makes genetic counseling a tricky issue for CLCN7-dependent osteopetrosis. Here, we characterize the first homozygous interstitial deletion in 16p13.3, detected by array comparative genomic hybridization in an ARO patient of Jordanian origin. The deletion involved other genes besides CLCN7, while the proband displayed a classic ARO phenotype; however, her early death did not allow more extensive clinical investigations. The identification of this novel genomic deletion involving a large part of the CLCN7 gene is of clinical relevance, especially in prenatal diagnosis, and suggests the possibility that this kind of mutation has been underestimated so far. These data highlight the need for alternative approaches to genetic analysis also in other ARO-causative genes.

Original languageEnglish
Pages (from-to)250-254
Number of pages5
JournalCalcified Tissue International
Volume91
Issue number4
DOIs
Publication statusPublished - Oct 2012

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Keywords

  • a-CGH
  • CLCN7
  • Deletion
  • Diagnosis
  • Osteopetrosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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