A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

David J. Vandenbergh, Antonio M. Persico, George R. Uhl

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3′ untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalMolecular Brain Research
Volume15
Issue number1-2
DOIs
Publication statusPublished - 1992

Keywords

  • Cocaine
  • Drug receptor
  • Parkinsonism
  • Tandem repeat
  • Tourette's syndrome

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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