A Human Homologue of the Drosophila Polarity Gene frizzled Has Been Identified and Mapped to 17q21.1

Zhaoyang Zhao, Cheng Chi Lee, Antonio Baldini, C. Thomas Caskey

Research output: Contribution to journalArticlepeer-review

Abstract

The friszled (fz) locus in Drosophila is required for the transmission of polarity signals across the plasma membrane in epidermal cells, as well as to their neighboring cells in the developing wing. The identification of a tissue polarity gene from the fz locus in Drosophila melanogasfer has been reported. The fz gene encodes a protein (Fz) with seven putative transmembrane domains, which was suggested to function as a G-protein-coupled receptor. Here we report the identification of a human homologue for the fz gene (FZD2). The FZD2 gene was isolated from a human ovarian cDNA library and mapped to 17q21.1 by fluorescent in situ hybridization (FISH) with a corresponding cosmid. The full-length cDNA of human FZD2 encodes a protein (FZD-2) of 565 amino acids that shares 56% sequence identity with Drosophila Fz. The expression of the FZD2 gene seems to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. The structure of FZD-2 suggests that it has a role in transmembrane signal transmission, although its precise physiological function and associated pathways are yet to be determined.

Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalGenomics
Volume27
Issue number2
DOIs
Publication statusPublished - May 20 1995

ASJC Scopus subject areas

  • Genetics

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