A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product

Silvia Pellegrini, Stefano Censini, Silvia Guidotti, Paola Iacopetti, Mariano Rocchi, Marco Bianchi, Antonello Covacci, Franco Gabrielli

Research output: Contribution to journalArticle

Abstract

We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.

Original languageEnglish
Pages (from-to)215-222
Number of pages8
JournalBBA - Gene Structure and Expression
Volume1574
Issue number3
DOIs
Publication statusPublished - Apr 12 2002

Keywords

  • Chromosome 14
  • Gene
  • Gene expression
  • Human
  • Short chain dehydrogenase/reductase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Structural Biology

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