Abstract
We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 215-222 |
| Number of pages | 8 |
| Journal | BBA - Gene Structure and Expression |
| Volume | 1574 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 12 2002 |
Keywords
- Chromosome 14
- Gene
- Gene expression
- Human
- Short chain dehydrogenase/reductase
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Genetics
- Structural Biology
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Pellegrini, S., Censini, S., Guidotti, S., Iacopetti, P., Rocchi, M., Bianchi, M., Covacci, A., & Gabrielli, F. (2002). A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product. BBA - Gene Structure and Expression, 1574(3), 215-222. https://doi.org/10.1016/S0167-4781(01)00323-2