A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product

Silvia Pellegrini; Stefano Censini; Silvia Guidotti; Paola Iacopetti; Mariano Rocchi; Marco Bianchi; Antonello Covacci; Franco Gabrielli

doi:10.1016/S0167-4781(01)00323-2

A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product

Silvia Pellegrini, Stefano Censini, Silvia Guidotti, Paola Iacopetti, Mariano Rocchi, Marco Bianchi, Antonello Covacci, Franco Gabrielli

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.

Original language	English
Pages (from-to)	215-222
Number of pages	8
Journal	BBA - Gene Structure and Expression
Volume	1574
Issue number	3
DOIs	https://doi.org/10.1016/S0167-4781(01)00323-2
Publication status	Published - Apr 12 2002

Keywords

Chromosome 14
Gene
Gene expression
Human
Short chain dehydrogenase/reductase

ASJC Scopus subject areas

Biochemistry
Biophysics
Genetics
Structural Biology

Access to Document

10.1016/S0167-4781(01)00323-2

Cite this

Pellegrini, S., Censini, S., Guidotti, S., Iacopetti, P., Rocchi, M., Bianchi, M., Covacci, A., & Gabrielli, F. (2002). A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product. BBA - Gene Structure and Expression, 1574(3), 215-222. https://doi.org/10.1016/S0167-4781(01)00323-2

Pellegrini, S, Censini, S, Guidotti, S, Iacopetti, P, Rocchi, M, Bianchi, M, Covacci, A & Gabrielli, F 2002, 'A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product', BBA - Gene Structure and Expression, vol. 1574, no. 3, pp. 215-222. https://doi.org/10.1016/S0167-4781(01)00323-2

@article{c46064eb0d0b436fbee225cba0f4158b,

title = "A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product",

abstract = "We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.",

keywords = "Chromosome 14, Gene, Gene expression, Human, Short chain dehydrogenase/reductase",

author = "Silvia Pellegrini and Stefano Censini and Silvia Guidotti and Paola Iacopetti and Mariano Rocchi and Marco Bianchi and Antonello Covacci and Franco Gabrielli",

year = "2002",

month = apr,

day = "12",

doi = "10.1016/S0167-4781(01)00323-2",

language = "English",

volume = "1574",

pages = "215--222",

journal = "Biochimica et Biophysica Acta - Gene Structure and Expression",

issn = "0167-4781",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - A human short-chain dehydrogenase/reductase gene

T2 - Structure, chromosomal localization, tissue expression and subcellular localization of its product

AU - Pellegrini, Silvia

AU - Censini, Stefano

AU - Guidotti, Silvia

AU - Iacopetti, Paola

AU - Rocchi, Mariano

AU - Bianchi, Marco

AU - Covacci, Antonello

AU - Gabrielli, Franco

PY - 2002/4/12

Y1 - 2002/4/12

N2 - We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.

AB - We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.

KW - Chromosome 14

KW - Gene

KW - Gene expression

KW - Human

KW - Short chain dehydrogenase/reductase

UR - http://www.scopus.com/inward/record.url?scp=0037066574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037066574&partnerID=8YFLogxK

U2 - 10.1016/S0167-4781(01)00323-2

DO - 10.1016/S0167-4781(01)00323-2

M3 - Article

C2 - 11997086

AN - SCOPUS:0037066574

VL - 1574

SP - 215

EP - 222

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

SN - 0167-4781

IS - 3

ER -

A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this