A juvenile case of conjunctival atypical nevus

Cristina Colarossi, Mario Milazzo, Milena Paglierani, Daniela Massi, Lorenzo Memeo, Vincenzo Canzonieri

Research output: Contribution to journalArticlepeer-review

Abstract

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2973228795724608. Melanocytic nevi are the most common tumors of the conjunctiva, accounting for 28% of all neoplastic lesions. These tumors, despite their benign behavior, share some atypical histological features with nevi found in other anatomic sites like the genital and acral regions, globally designated as nevi with site-related atypia. Moreover, in children and adolescents, rapidly growing conjunctival nevi show sometimes worrisome histological patterns in association with a prominent inflammatory infiltrate that may lead to diagnostic problems. In this paper we describe a juvenile compound nevus characterized by marked melanocytic atypia and severe inflammation, which can be considered a rare case of juvenile conjunctival atypical nevus. The final diagnosis relied on morphological and immunohistochemical characterization of the large epithelioid melanocytic cells, and on the results of FISH analysis.

Original languageEnglish
Article number64
JournalDiagnostic Pathology
Volume8
Issue number1
DOIs
Publication statusPublished - Apr 22 2013

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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