A K+ channel activated by cholinergic muscarinic receptors in chick ciliary ganglion neurons at early developmental stage

Carla Distasi, Alessandra Gilardino, Jessica Erriquez, Pollyanna Zamburlin, Davide Lovisolo

Research output: Contribution to journalArticlepeer-review

Abstract

Embryonic chick ciliary ganglion (CG) neurons obtained from E7-E8 ganglia maintained in serum-free medium were stimulated with 50 μM muscarine. A fast hyperpolarization of the membrane potential was observed in 25% of the cells tested, that in some cases was associated with a slower depolarization. Accordingly, in voltage clamp experiments, either an outward current or a biphasic current response could be observed. Single-channel experiments provide evidence that these signals can be associated to the activation of a K + channel whose conductance is 20 pS.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalBrain Research
Volume991
Issue number1-2
DOIs
Publication statusPublished - Nov 21 2003

Keywords

  • Chick embryo neuron
  • Ciliary ganglion
  • Muscarinic acetylcholine receptor
  • Potassium channel

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'A K+ channel activated by cholinergic muscarinic receptors in chick ciliary ganglion neurons at early developmental stage'. Together they form a unique fingerprint.

Cite this