A kallikrein-like enzyme in blood vessels of one-kidney, one clip hypertensive rats

H. Nolly, O. A. Carretero, G. Scicli, P. Madeddu, A. G. Scicli

Research output: Contribution to journalArticle

Abstract

Active and inactive kallikrein or a kallikrein-like enzyme are found in the aorta, vena cava, and tail artery and veins of the rat. We studied the concentration of vascular kininogenase in rats with one-kidney, one clip renovascular hypertension and in unilaterally nephrectomized normotensive rats. Six weeks after surgery, active and total vascular kininogenase activity (active plus trypsin-activated) was measured. Blood pressure was 212 ± 4 mm Hg in the hypertensive rats (n = 33) and 120 ± 1 mm Hg in the normotensive rats (n = 32) (p <0.001). Active kininogenase was lower in the hypertensive rats; although the difference was not significant in the thoracic aorta (56 ± 8 versus 77 ± 15), it was highly signficant in the abdominal aorta (63 ± 13 versus 167 ± 17, p <0.001) and tail artery (48 ± 8 versus 197 ± 31, p <0.003). Total vascular kininogenase activity (active plus trypsin-activated) was lower in the hypertensive rats in all arteries examined: thoracic aorta (183 ± 16 versus 380 ± 38, p <0.003), abdominal aorta (565 ± 61 versus 1,093 ±74, p <0.001), and tail artery (532 ± 112 versus 1,243 ± 135, p <0.003). Active kininogenase in the vena cava was higher in the hypertensive rats (213 ± 56 versus 131 ± 31); however, this difference was not statistically significant, whereas in the tail veins it was highly significant (1,803 ± 221 versus 771 ± 79, p <0.003). Total venous kininogenase activity was significantly higher in the hypertensive rats (vena cava, 1.850 ± 171 versus 998 ± 149, p <0.01; tail vein, 4,261 ± 261 versus 2,521 ± 212, p <0.001). In conclusion, we found that in rats with one-kidney, one clip renovascular hypertension both active and total vascular kininogenase are decreased in the arteries and increased in veins. These changes may contribute to the pathogenesis of hypertension.

Original languageEnglish
Pages (from-to)436-440
Number of pages5
JournalHypertension
Volume16
Issue number4
Publication statusPublished - 1990

Keywords

  • blood pressure
  • Goldblatt hypertension
  • kallikrein
  • kinins
  • slow-reacting substance
  • vascular tissue

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Nolly, H., Carretero, O. A., Scicli, G., Madeddu, P., & Scicli, A. G. (1990). A kallikrein-like enzyme in blood vessels of one-kidney, one clip hypertensive rats. Hypertension, 16(4), 436-440.