A kindred affected by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). A 2-year neuropsychological follow-up

Luigi Trojano, Michele Ragno, Antonio Manca, Giuseppe Caruso

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We report a 2-year prospective neuropsychological study of five asymptomatic subjects with magnetic resonance imaging (MRI) abnormalities from an Italian kindred affected by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). These subjects completed tests for attention capacities, processing speed, abstract thinking, short-term memory, learning and constructional praxis. Seven normal subjects matched for age and education, belonging to the same pedigree and not having MRI hyperintensities were examined as controls. The results did not show significant differences between asymptomatic subjects and normal controls. Cognitive performance of asymptomatic subjects did not deteriorate during a 2-year follow-up. Our findings suggest that, at this stage of the disease process, the presence of diffuse leukoencephalopathy does not imply subtle cognitive defects.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalJournal of Neurology
Volume245
Issue number4
DOIs
Publication statusPublished - 1998

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CADASIL
Magnetic Resonance Imaging
Leukoencephalopathies
Pedigree
Short-Term Memory
Learning
Prospective Studies
Education

Keywords

  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
  • Cognition
  • Dominant inheritance
  • Magnetic resonance imaging
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

A kindred affected by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). A 2-year neuropsychological follow-up. / Trojano, Luigi; Ragno, Michele; Manca, Antonio; Caruso, Giuseppe.

In: Journal of Neurology, Vol. 245, No. 4, 1998, p. 217-222.

Research output: Contribution to journalArticle

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