A left atrial appendage closure combined procedure review: Past, present, and future perspectives

Alessio Gasperetti, Gaetano Fassini, Fabrizio Tundo, Martina Zucchetti, Mariantonietta Dessanai, Claudio Tondo

Research output: Contribution to journalReview articlepeer-review


Background and Objective: Atrial fibrillation (AF) represents the most common cardiac arrhythmia worldwide; it poses a great burden in terms of quality of life reduction and yearly stroke risk. Left atrial appendage closure (LAAC) is a stroke prevention strategy that has been proven a viable alternative to antithrombotic regimens in nonvalvular AF patients. LAAC can be performed as a standalone procedure or alongside a concomitant AF transcatheter ablation, in a procedure known as “Combined procedure”. Aim of this study is to summarize the scientific evidence backing this combined strategy. Methods: We reviewed the whole Medline indexed combined procedure literature, to summarize all the combined procedure study data. Results: Nine published studies regarding combined procedure were found. Data, aims, and scientific rationales were reported and commented. Conclusion: LAA combined procedure appears to be a safe and effective procedure; a careful patient selection is necessary to maximize its benefit.

Original languageEnglish
Pages (from-to)1345-1351
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Issue number8
Publication statusPublished - Jan 1 2019


  • atrial fibrillation
  • catheter ablation
  • combined ablation
  • left atrial appendage
  • left atrial appendage closure
  • review
  • stroke prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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