A "live" biopsy in a small-cell lung cancer patient by detection of circulating tumor cells

Simona Bevilacqua; Marianna Gallo; Renato Franco; Antonio Rossi; Antonella De Luca; Gaetano Rocco; Gerardo Botti; Cesare Gridelli; Nicola Normanno

doi:10.1016/j.lungcan.2009.01.019

A "live" biopsy in a small-cell lung cancer patient by detection of circulating tumor cells

Simona Bevilacqua, Marianna Gallo, Renato Franco, Antonio Rossi, Antonella De Luca, Gaetano Rocco, Gerardo Botti, Cesare Gridelli, Nicola Normanno

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

A 71-year-old patient with a pulmonary lesion was diagnosed with a low-grade neuroendocrine tumor following examination of a fine needle aspiration biopsy. Analysis of a peripheral blood sample with the CellSearch™ system revealed the presence of putative circulating tumor cells (CTC) that were positive for EpCAM and cytokeratin (CK) expression. Since EpCAM is not usually expressed in neuroendocrine tumors, we performed a biopsy of liver metastases. Morphological and immunophenotypical characterization revealed that the patient had an EpCAM and CK positive small-cell lung cancer (SCLC). By using the CellSearch™ apparatus, EpCAM/CK positive CTC were detected in peripheral blood samples from 3 out of 4 additional SCLC patients. This study is the first to demonstrate that CTC can be identified in SCLC patients by using the CellSearch™ system.

Original language	English
Pages (from-to)	123-125
Number of pages	3
Journal	Lung Cancer
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/j.lungcan.2009.01.019
Publication status	Published - Jul 2009

Keywords

Circulating tumor cells
Diagnosis
SCLC

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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A "live" biopsy in a small-cell lung cancer patient by detection of circulating tumor cells. / Bevilacqua, Simona ; Gallo, Marianna; Franco, Renato; Rossi, Antonio; De Luca, Antonella; Rocco, Gaetano; Botti, Gerardo; Gridelli, Cesare; Normanno, Nicola.

In: Lung Cancer, Vol. 65, No. 1, 07.2009, p. 123-125.

Research output: Contribution to journal › Article › peer-review

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AU - Rocco, Gaetano

AU - Botti, Gerardo

AU - Gridelli, Cesare

AU - Normanno, Nicola

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