A locus for migraine without aura maps on chromosome 14q21.2-q22.3

Debora Soragna, A. Vettori, G. Carraro, E. Marchioni, G. Vazza, S. Bellini, R. Tupler, F. Savoldi, M. L. Mostacciuolo

Research output: Contribution to journalArticle

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Abstract

Migraine is a common and disabling neurological disease of unknown origin characterized by a remarkable clinical variability. It shows strong familial aggregation, suggesting that genetic factors are involved in its pathogenesis. Different approaches have been used to elucidate this hereditary component, but a unique transmission model and causative gene(s) have not yet been identified. We report clinical and molecular data from a large Italian pedigree in which migraine without aura (MO) segregates as an autosomal dominant trait. After exclusion of any association between MO and the known familial hemiplegic migraine and migraine with aura loci, we performed a genomewide linkage analysis using 482 polymorphic microsatellite markers. We obtained significant evidence of linkage between the MO phenotype and the marker D14S978 on 14q22.1 (maximum two-point LOD score of 3.70, at a recombination fraction of 0.01). Multipoint parametric analysis (maximum LOD score of 5.25 between markers D14S976 and D14S978) and haplotype construction showed strong evidence of linkage in a region of 10 cM flanked by markers D14S1027 and D14S980 on chromosome 14q21.2-q22.3. These results indicate the first evidence of a genetic locus associated with MO on chromosome 14.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalAmerican Journal of Human Genetics
Volume72
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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Migraine without Aura
Migraine with Aura
Chromosomes
Chromosomes, Human, Pair 14
Genetic Loci
Pedigree
Migraine Disorders
Microsatellite Repeats
Haplotypes
Genetic Recombination
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics

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Soragna, D., Vettori, A., Carraro, G., Marchioni, E., Vazza, G., Bellini, S., ... Mostacciuolo, M. L. (2003). A locus for migraine without aura maps on chromosome 14q21.2-q22.3. American Journal of Human Genetics, 72(1), 161-167. https://doi.org/10.1086/345298

A locus for migraine without aura maps on chromosome 14q21.2-q22.3. / Soragna, Debora; Vettori, A.; Carraro, G.; Marchioni, E.; Vazza, G.; Bellini, S.; Tupler, R.; Savoldi, F.; Mostacciuolo, M. L.

In: American Journal of Human Genetics, Vol. 72, No. 1, 01.01.2003, p. 161-167.

Research output: Contribution to journalArticle

Soragna, D, Vettori, A, Carraro, G, Marchioni, E, Vazza, G, Bellini, S, Tupler, R, Savoldi, F & Mostacciuolo, ML 2003, 'A locus for migraine without aura maps on chromosome 14q21.2-q22.3', American Journal of Human Genetics, vol. 72, no. 1, pp. 161-167. https://doi.org/10.1086/345298
Soragna, Debora ; Vettori, A. ; Carraro, G. ; Marchioni, E. ; Vazza, G. ; Bellini, S. ; Tupler, R. ; Savoldi, F. ; Mostacciuolo, M. L. / A locus for migraine without aura maps on chromosome 14q21.2-q22.3. In: American Journal of Human Genetics. 2003 ; Vol. 72, No. 1. pp. 161-167.
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