A long-lasting cholinesterase inhibitor affecting neural and behavioral processes

M. Brufani; C. Castellano; M. Marta; A. Oliverio; P. G. Pagella; F. Pavone; M. Pomponi; P. L. Rugarli

doi:10.1016/0091-3057(87)90176-6

A long-lasting cholinesterase inhibitor affecting neural and behavioral processes

M. Brufani, C. Castellano, M. Marta, A. Oliverio, P. G. Pagella, F. Pavone, M. Pomponi, P. L. Rugarli

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.

Original language	English
Pages (from-to)	625-629
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(87)90176-6
Publication status	Published - 1987

Keywords

Aging
Cholinergic mechanism
Memory
Physostigmine derivatives

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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abstract = "A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.",

keywords = "Aging, Cholinergic mechanism, Memory, Physostigmine derivatives",

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T1 - A long-lasting cholinesterase inhibitor affecting neural and behavioral processes

AU - Brufani, M.

AU - Castellano, C.

AU - Marta, M.

AU - Oliverio, A.

AU - Pagella, P. G.

AU - Pavone, F.

AU - Pomponi, M.

AU - Rugarli, P. L.

PY - 1987

Y1 - 1987

N2 - A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.

AB - A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.

KW - Aging

KW - Cholinergic mechanism

KW - Memory

KW - Physostigmine derivatives

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AN - SCOPUS:0023100482

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SP - 625

EP - 629

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -

A long-lasting cholinesterase inhibitor affecting neural and behavioral processes

Abstract

Keywords

ASJC Scopus subject areas

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