Abstract
A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.
Original language | English |
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Pages (from-to) | 625-629 |
Number of pages | 5 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 26 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1987 |
Keywords
- Aging
- Cholinergic mechanism
- Memory
- Physostigmine derivatives
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology