A long-lasting cholinesterase inhibitor affecting neural and behavioral processes

M. Brufani, C. Castellano, M. Marta, A. Oliverio, P. G. Pagella, F. Pavone, M. Pomponi, P. L. Rugarli

Research output: Contribution to journalArticlepeer-review


A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number3
Publication statusPublished - 1987


  • Aging
  • Cholinergic mechanism
  • Memory
  • Physostigmine derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology


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