A long-term prospective evaluation of first-degree relatives of panic patients who underwent the 35% CO2 challenge

Giampaolo Perna, Silvia Cocchi, Liliana Allevi, Riccardo Bussi, Laura Bellodi

Research output: Contribution to journalArticle

Abstract

Background: This follow-up study investigated the potential priming effect of the 35% CO2 challenge on the development of anxiety disorders and/or panic attacks in healthy first-degree relatives of panic patients across a period of 3-4 years subsequent to the challenge. Methods: Thirty- one relatives who underwent the 35% CO2 challenge 3-4 years before and 14 relatives, free from psychiatric diagnoses in the same period, were directly reevaluated for the presence of anxiety disorders and panic attacks. Results: None developed anxiety disorders and only 1, among relatives previously tested with the 35% CO2 challenge, reported sporadic panic attacks. Conclusions: The 35% CO2 challenge is a safe research paradigm in the investigation of healthy subjects with a familial vulnerability to panic, and CO2 hypersensitivity might be considered a trait marker of an underlying familial vulnerability to panic disorder.

Original languageEnglish
Pages (from-to)365-367
Number of pages3
JournalBiological Psychiatry
Volume45
Issue number3
DOIs
Publication statusPublished - Feb 1 1999

Keywords

  • Carbon dioxide
  • Genetic
  • Panic disorder
  • Provocation
  • Safety

ASJC Scopus subject areas

  • Biological Psychiatry

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