A longitudinal EEG study of Alzheimer's disease progression based on a complex network approach

Francesco Carlo Morabito, Maurizio Campolo, Domenico Labate, Giuseppe Morabito, Lilla Bonanno, Alessia Bramanti, Simona De Salvo, Angela Marra, Placido Bramanti

Research output: Contribution to journalArticlepeer-review


A complex network approach is combined with time dynamics in order to conduct a space-time analysis applicable to longitudinal studies aimed to characterize the progression of Alzheimer's disease (AD) in individual patients. The network analysis reveals how patient-specific patterns are associated with disease progression, also capturing the widespread effect of local disruptions. This longitudinal study is carried out on resting electroence phalography (EEGs) of seven AD patients. The test is repeated after a three months' period. The proposed methodology allows to extract some averaged information and regularities on the patients' cohort and to quantify concisely the disease evolution. From the functional viewpoint, the progression of AD is shown to be characterized by a loss of connected areas here measured in terms of network parameters (characteristic path length, clustering coefficient, global efficiency, degree of connectivity and connectivity density). The differences found between baseline and at follow-up are statistically significant. Finally, an original topographic multiscale approach is proposed that yields additional results.

Original languageEnglish
Article number1550005
JournalInternational Journal of Neural Systems
Issue number2
Publication statusPublished - Mar 25 2015


  • Alzheimer's disease
  • complex networks
  • complexity
  • longitudinal EEG database
  • multiscale temporal analysis
  • mutual information

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Medicine(all)


Dive into the research topics of 'A longitudinal EEG study of Alzheimer's disease progression based on a complex network approach'. Together they form a unique fingerprint.

Cite this