A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus

Marite Rygg, Angela Pistorio, Angelo Ravelli, Mohamad Maghnie, Natascia Di Iorgi, Brigitte Bader-Meunier, Carlos Da Silva, Rosa Roldan-Molina, Judith Barash, Cristina Dracou, Sylvie Gandon Laloum, Katerina Jarosova, Chantal Job Deslandre, Isabelle Koné-Paut, Franco Garofalo, Joseph Press, Claudia Sengler, Tsivia Tauber, Alberto Martini, Nicolino Ruperto

Research output: Contribution to journalArticle

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Abstract

Objective: To obtain longitudinal data on growth/puberty in a large-scale, multi-national prospective cohort of juvenile systemic lupus erythematosus (SLE). Methods: Data from 331/557 (59.4%) patients ≤18 years old with juvenile SLE in active phase, with anthropometric data available at four follow-up visits, were studied. Results: There was a significant reduction in parent-adjusted height z score with time in females and males (p426 mg/kg (OR: 3.6). Conclusions: The children at risk of having a negative effect on height and pubertal development are prepubertal and peripubertal children treated with >400 mg/kg cumulative dose of corticosteroids.

Original languageEnglish
Pages (from-to)511-517
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume71
Issue number4
DOIs
Publication statusPublished - Apr 2012

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Puberty
Systemic Lupus Erythematosus
Longitudinal Studies
Adrenal Cortex Hormones
Growth

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus. / Rygg, Marite; Pistorio, Angela; Ravelli, Angelo; Maghnie, Mohamad; Iorgi, Natascia Di; Bader-Meunier, Brigitte; Da Silva, Carlos; Roldan-Molina, Rosa; Barash, Judith; Dracou, Cristina; Laloum, Sylvie Gandon; Jarosova, Katerina; Deslandre, Chantal Job; Koné-Paut, Isabelle; Garofalo, Franco; Press, Joseph; Sengler, Claudia; Tauber, Tsivia; Martini, Alberto; Ruperto, Nicolino.

In: Annals of the Rheumatic Diseases, Vol. 71, No. 4, 04.2012, p. 511-517.

Research output: Contribution to journalArticle

Rygg, M, Pistorio, A, Ravelli, A, Maghnie, M, Iorgi, ND, Bader-Meunier, B, Da Silva, C, Roldan-Molina, R, Barash, J, Dracou, C, Laloum, SG, Jarosova, K, Deslandre, CJ, Koné-Paut, I, Garofalo, F, Press, J, Sengler, C, Tauber, T, Martini, A & Ruperto, N 2012, 'A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus', Annals of the Rheumatic Diseases, vol. 71, no. 4, pp. 511-517. https://doi.org/10.1136/annrheumdis-2011-200106
Rygg, Marite ; Pistorio, Angela ; Ravelli, Angelo ; Maghnie, Mohamad ; Iorgi, Natascia Di ; Bader-Meunier, Brigitte ; Da Silva, Carlos ; Roldan-Molina, Rosa ; Barash, Judith ; Dracou, Cristina ; Laloum, Sylvie Gandon ; Jarosova, Katerina ; Deslandre, Chantal Job ; Koné-Paut, Isabelle ; Garofalo, Franco ; Press, Joseph ; Sengler, Claudia ; Tauber, Tsivia ; Martini, Alberto ; Ruperto, Nicolino. / A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus. In: Annals of the Rheumatic Diseases. 2012 ; Vol. 71, No. 4. pp. 511-517.
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AU - Pistorio, Angela

AU - Ravelli, Angelo

AU - Maghnie, Mohamad

AU - Iorgi, Natascia Di

AU - Bader-Meunier, Brigitte

AU - Da Silva, Carlos

AU - Roldan-Molina, Rosa

AU - Barash, Judith

AU - Dracou, Cristina

AU - Laloum, Sylvie Gandon

AU - Jarosova, Katerina

AU - Deslandre, Chantal Job

AU - Koné-Paut, Isabelle

AU - Garofalo, Franco

AU - Press, Joseph

AU - Sengler, Claudia

AU - Tauber, Tsivia

AU - Martini, Alberto

AU - Ruperto, Nicolino

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AB - Objective: To obtain longitudinal data on growth/puberty in a large-scale, multi-national prospective cohort of juvenile systemic lupus erythematosus (SLE). Methods: Data from 331/557 (59.4%) patients ≤18 years old with juvenile SLE in active phase, with anthropometric data available at four follow-up visits, were studied. Results: There was a significant reduction in parent-adjusted height z score with time in females and males (p426 mg/kg (OR: 3.6). Conclusions: The children at risk of having a negative effect on height and pubertal development are prepubertal and peripubertal children treated with >400 mg/kg cumulative dose of corticosteroids.

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