A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus

Marite Rygg, Angela Pistorio, Angelo Ravelli, Mohamad Maghnie, Natascia Di Iorgi, Brigitte Bader-Meunier, Carlos Da Silva, Rosa Roldan-Molina, Judith Barash, Cristina Dracou, Sylvie Gandon Laloum, Katerina Jarosova, Chantal Job Deslandre, Isabelle Koné-Paut, Franco Garofalo, Joseph Press, Claudia Sengler, Tsivia Tauber, Alberto Martini, Nicolino Ruperto

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To obtain longitudinal data on growth/puberty in a large-scale, multi-national prospective cohort of juvenile systemic lupus erythematosus (SLE). Methods: Data from 331/557 (59.4%) patients ≤18 years old with juvenile SLE in active phase, with anthropometric data available at four follow-up visits, were studied. Results: There was a significant reduction in parent-adjusted height z score with time in females and males (p426 mg/kg (OR: 3.6). Conclusions: The children at risk of having a negative effect on height and pubertal development are prepubertal and peripubertal children treated with >400 mg/kg cumulative dose of corticosteroids.

Original languageEnglish
Pages (from-to)511-517
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume71
Issue number4
DOIs
Publication statusPublished - Apr 2012

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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