TY - JOUR
T1 - A longitudinal skin biopsy study of phosphorylated alpha-synuclein in a patient with Parkinson disease and orthostatic hypotension
AU - Infante, Rossella
AU - Scaglione, Cesa
AU - Incensi, Alex
AU - Rizzo, Giovanni
AU - Liguori, Rocco
AU - Donadio, Vincenzo
N1 - Ricercatore distaccato presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Rizzo Giovanni, Liguori Rocco)
PY - 2020/7/1
Y1 - 2020/7/1
N2 - The aim of our study was to assess the distribution of phosphorylated a-synuclein (p-syn) deposits in a patient affected by early stage Parkinson disease and orthostatic hypotension through a longitudinal skin biopsy study. We found widespread p-syn spatial diffusion from deep autonomic dermis nerve bundles to autonomic terminals, suggesting a centrifugal spread of p-syn from ganglia to the innervation target structures. Furthermore, the case suggests the possibility of discriminating synucleinopathies at an early stage of disease by means of skin biopsy. If confirmed, these data support skin biopsy as a useful and promising tool for the diagnosis, longitudinal evaluation, and pathological understanding of Parkinson disease.
AB - The aim of our study was to assess the distribution of phosphorylated a-synuclein (p-syn) deposits in a patient affected by early stage Parkinson disease and orthostatic hypotension through a longitudinal skin biopsy study. We found widespread p-syn spatial diffusion from deep autonomic dermis nerve bundles to autonomic terminals, suggesting a centrifugal spread of p-syn from ganglia to the innervation target structures. Furthermore, the case suggests the possibility of discriminating synucleinopathies at an early stage of disease by means of skin biopsy. If confirmed, these data support skin biopsy as a useful and promising tool for the diagnosis, longitudinal evaluation, and pathological understanding of Parkinson disease.
KW - A-Synuclein
KW - Multiple system atrophy
KW - Orthostatic hypotension
KW - Parkinson disease
KW - Skin biopsy
UR - http://www.scopus.com/inward/record.url?scp=85086793153&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086793153&partnerID=8YFLogxK
U2 - 10.1093/jnen/nlaa048
DO - 10.1093/jnen/nlaa048
M3 - Article
C2 - 32529258
AN - SCOPUS:85086793153
VL - 79
SP - 813
EP - 816
JO - American Journal of Psychotherapy
JF - American Journal of Psychotherapy
SN - 0002-9564
IS - 7
ER -