A low FODMAP gluten-free diet improves functional gastrointestinal disorders and overall mental health of celiac disease patients: A randomized controlled trial

Leda Roncoroni, Karla A. Bascuñán, Luisa Doneda, Alice Scricciolo, Vincenza Lombardo, Federica Branchi, Francesca Ferretti, Bernardo Dell’osso, Valeria Montanari, Maria Teresa Bardella, Luca Elli

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Abstract

A subset of patients with celiac disease (CD) on a gluten-free diet (GFD) reported the persistence of functional gastrointestinal disorders. Foods containing fermentable, oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) can trigger a broad range of gastrointestinal symptoms in sensitive individuals. We evaluated the effects of a low FODMAP diet (LFD) on gastrointestinal and psychological symptomatology in CD patients. A total of 50 celiac patients on GFDs and with persistence of gastrointestinal symptoms were included. The patients were randomly allocated to one of two dietary groups—one on a low FODMAP GFD (LF-GFD, n = 25) and the other on a regular GFD (R-GFD, n = 25)—for 21 days. Psychological symptomatology and quality of life were evaluated by the Symptom Checklist-90-R (SCL-90) and the Short Form (36) Health Survey (SF-36) questionnaires, respectively. Gastrointestinal symptomatology and general well-being were evaluated by visual analogue scale (VAS) scores. After 21 days, 21 and 23 patients completed the dietary treatment on LF-GFD and R-GFD, respectively. A reduced global SCL-90 index (p < 0.0003) was found in the LF-GFD group but not in the R-GFD one. However, the SF-36 scores did not differ between groups after treatment. The VAS for abdominal pain was much lower, and the VAS for fecal consistency enhanced after treatment in the LF-GFD group. General well-being increased in both groups but with a much higher improvement in the LF-GFD (p = 0.03). A short-term LFD regimen helps to improve the psychological health and gastrointestinal symptomatology with enhanced well-being of CD patients with persisting functional gastrointestinal symptomatology. The long-term clinical effects of LFD in particular subgroups of CD patients need further evaluation.

Original languageEnglish
Article number1023
JournalNutrients
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 4 2018

Fingerprint

gluten-free diet
Gluten-Free Diet
mental health
celiac disease
polyols
Monosaccharides
Gastrointestinal Diseases
Disaccharides
disaccharides
Celiac Disease
monosaccharides
digestive system diseases
Oligosaccharides
oligosaccharides
Mental Health
Randomized Controlled Trials
signs and symptoms (animals and humans)
Visual Analog Scale
Psychology
Diet

Keywords

  • Gastrointestinal symptoms
  • Gluten-free diet
  • Quality of life

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

A low FODMAP gluten-free diet improves functional gastrointestinal disorders and overall mental health of celiac disease patients : A randomized controlled trial. / Roncoroni, Leda; Bascuñán, Karla A.; Doneda, Luisa; Scricciolo, Alice; Lombardo, Vincenza; Branchi, Federica; Ferretti, Francesca; Dell’osso, Bernardo; Montanari, Valeria; Bardella, Maria Teresa; Elli, Luca.

In: Nutrients, Vol. 10, No. 8, 1023, 04.08.2018.

Research output: Contribution to journalArticle

Roncoroni, Leda ; Bascuñán, Karla A. ; Doneda, Luisa ; Scricciolo, Alice ; Lombardo, Vincenza ; Branchi, Federica ; Ferretti, Francesca ; Dell’osso, Bernardo ; Montanari, Valeria ; Bardella, Maria Teresa ; Elli, Luca. / A low FODMAP gluten-free diet improves functional gastrointestinal disorders and overall mental health of celiac disease patients : A randomized controlled trial. In: Nutrients. 2018 ; Vol. 10, No. 8.
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