Abstract
After coronary artery bypass grafting (CABG), the hemodynamic conditions experienced by the saphenous veins are similar to those experienced by coronary arteries: pulsatile pressure (80-120 mmHg), pulsatile flow (mean flow rate of 250 ml/min), and elevated shear stress (1-7 Pa). Here we present a novel pulsatile platform for studying the human saphenous vein early remodeling events after CABG. The system was designed in order to apply CABG-like pressure/flow stimulation patterns to the hosted human saphenous vein segments, i.e. a pulsatile pressure oscillating between a diastolic minimum and a systolic maximum in counter-phase with a pulsatile flow rate. Functional tests revealed good fitting of simulated and measured tracings and the ability of the pulsatile platform to mimic the complexity of the coronary hemodynamic environment with good fidelity in comparison with state-of-the-art devices. This system will enable us to study the biological response of human saphenous veins to CABG conditioning ex vivo, in currently ongoing experiments.
Original language | English |
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Title of host publication | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 2588-2591 |
Number of pages | 4 |
Volume | 2015-November |
ISBN (Print) | 9781424492718 |
DOIs | |
Publication status | Published - Nov 4 2015 |
Event | 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: Aug 25 2015 → Aug 29 2015 |
Other
Other | 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 |
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Country/Territory | Italy |
City | Milan |
Period | 8/25/15 → 8/29/15 |
ASJC Scopus subject areas
- Computer Vision and Pattern Recognition
- Signal Processing
- Biomedical Engineering
- Health Informatics