A MAGE-A4 peptide presented by HLA-B37 is recognized on human tumors by cytolytic T lymphocytes

Y. Zhang, V. Stroobant, V. Russo, T. Boon, Pierre Van der Bruggen

Research output: Contribution to journalArticlepeer-review

Abstract

'Cancer-germline' genes such as those of the MAGE family are expressed in many tumors and in male germline cells, but are silent in normal tissues. They encode shared tumor-specific antigens, which have been used in therapeutic vaccination trials of cancer patients. MAGE-A4 is expressed in more than 50% of carcinomas of esophagus, head and neck, lung, and bladder. We report here the identification of a new MAGE-A4 encoded peptide, which is recognized by a cytolytic T lymphocyte (CTL) clone on HLA-B*3701. The sequence of the peptide is SESLKMIF. It corresponds to the MAGE-A4156-163 protein sequence. When tumor cells expressing MAGE-A4 were transfected with HLA-B*3701, they were recognized by the CTL clone, demonstrating that the peptide ought to be processed in tumor cells and could therefore serve as a target for therapeutic antitumoral vaccination.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalTissue Antigens
Volume60
Issue number5
DOIs
Publication statusPublished - Nov 1 2002

Keywords

  • Antigenic peptide
  • CTL
  • HLA-B37
  • MAGE-A4
  • Tumor

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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