A magnetization transfer study of mild and advanced Parkinson's disease

N. Tambasco, V. Belcastro, P. Sarchielli, P. Floridi, L. Pierguidi, C. Menichetti, A. Castrioto, P. Chiarini, L. Parnetti, P. Eusebi, P. Calabresi, A. Rossi

Research output: Contribution to journalArticlepeer-review


Background and purpose: Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson's disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2). Methods: We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age-matched subjects. Results: Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus. Conclusion: These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalEuropean Journal of Neurology
Issue number3
Publication statusPublished - Mar 2011


  • Basal ganglia
  • Magnetic resonance imaging
  • Magnetization transfer ratio
  • Parkinson's disease
  • Substantia nigra
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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