A mathematical approach for evaluating the influence of dose heterogeneity on TCP for prostate cancer brachytherapy treatment

L. Strigari, L. C. Orlandini, I. Andriani, A. D'Angelo, M. Stefanacci, A. M. Di Nallo, Marcello Benassi

Research output: Contribution to journalArticlepeer-review

Abstract

The low-dose-rate brachytherapy technique has proven suitable for the management of prostate cancer. However, published data generally report the clinical outcome and the minimum peripheral dose (mPD) to the target volume and not the actual dose distribution in patients. To this end, modern guidelines recommend the use of specific dose and volume indices describing dose distribution throughout the target. The introduction of a method, based on the standard linear quadratic model and Poisson statistics, entitled the F-factor allows the TCP from different DVHs to be calculated, by using the TCP from a uniform dose distribution as the reference. The F-factor sensitivity against radiobiological parameters and influence of the DVH were evaluated. We applied the F-formula on the post-plan DVHs of 58 patients treated with 125I permanent seed implant brachytherapy for localized prostate cancer. F shows a strong correlation with dosimetric parameters already reported as significant predictors of the biochemical outcome.

Original languageEnglish
Pages (from-to)5045-5059
Number of pages15
JournalPhysics in Medicine and Biology
Volume53
Issue number18
DOIs
Publication statusPublished - Sep 21 2008

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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