A Mathematical Model for the Immunosenescence

Fabio Luciani, Giorgio Turchetti, Claudio Franceschi, Silvana Valensin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We propose a model for the dynamics of the immune system by considering the subpopulations of virgin and memory T lymphocytes on a time scale corresponding to the human life span. In the deterministic balance equation we introduce a fluctuating term in order to take into account the chronic antigenic stress. Starting from the hypothesis that the depletion of virgin cells with cytotoxicproperties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves.

Original languageEnglish
Pages (from-to)305-318
Number of pages14
JournalRivista di Biologia - Biology Forum
Volume94
Issue number2
Publication statusPublished - May 2001

Fingerprint

dynamic models
immune system
Immune System
Theoretical Models
mathematical models
demographic statistics
T-lymphocytes
Demography
T-Lymphocytes
Survival
Mortality
cells
Immunosenescence

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Luciani, F., Turchetti, G., Franceschi, C., & Valensin, S. (2001). A Mathematical Model for the Immunosenescence. Rivista di Biologia - Biology Forum, 94(2), 305-318.

A Mathematical Model for the Immunosenescence. / Luciani, Fabio; Turchetti, Giorgio; Franceschi, Claudio; Valensin, Silvana.

In: Rivista di Biologia - Biology Forum, Vol. 94, No. 2, 05.2001, p. 305-318.

Research output: Contribution to journalArticle

Luciani, F, Turchetti, G, Franceschi, C & Valensin, S 2001, 'A Mathematical Model for the Immunosenescence', Rivista di Biologia - Biology Forum, vol. 94, no. 2, pp. 305-318.
Luciani F, Turchetti G, Franceschi C, Valensin S. A Mathematical Model for the Immunosenescence. Rivista di Biologia - Biology Forum. 2001 May;94(2):305-318.
Luciani, Fabio ; Turchetti, Giorgio ; Franceschi, Claudio ; Valensin, Silvana. / A Mathematical Model for the Immunosenescence. In: Rivista di Biologia - Biology Forum. 2001 ; Vol. 94, No. 2. pp. 305-318.
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