A Mathematical Model for the Immunosenescence

Fabio Luciani, Giorgio Turchetti, Claudio Franceschi, Silvana Valensin

Research output: Contribution to journalArticle

Abstract

We propose a model for the dynamics of the immune system by considering the subpopulations of virgin and memory T lymphocytes on a time scale corresponding to the human life span. In the deterministic balance equation we introduce a fluctuating term in order to take into account the chronic antigenic stress. Starting from the hypothesis that the depletion of virgin cells with cytotoxicproperties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves.

Original languageEnglish
Pages (from-to)305-318
Number of pages14
JournalRivista di Biologia - Biology Forum
Volume94
Issue number2
Publication statusPublished - May 2001

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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    Luciani, F., Turchetti, G., Franceschi, C., & Valensin, S. (2001). A Mathematical Model for the Immunosenescence. Rivista di Biologia - Biology Forum, 94(2), 305-318.