A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial.

Eleonora Bruno, Andreina Oliverio, Angelo Virgilio Paradiso, Antonella Daniele, Stefania Tommasi, Antonio Tufaro, Daniela Andreina Terribile, Stefano Magno, Alessio Filippone, Elisabetta Venturelli, Daniele Morelli, Ivan Baldassari, Maria Luisa Cravana, Siranoush Manoukian, Patrizia Pasanisi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Women carriers of BRCA1/2 mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. Methods: BRCA carriers, with or without a previous cancer, aged 18-70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. Results: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (-11.3 ng/mL versus -1.3 ng/mL, p = 0.02), weight (-1.5 Kg versus -0.5 Kg, p textless 0.001), waist circumference (-2 cm versus -0.7 cm, p = 0.01), hip circumference (-1.6 cm versus -0.5 cm, p = 0.01), total cholesterol (-10.2 mg/dL versus -3.6 mg/dL, p = 0.04) and triglycerides (-8.7 mg/dL versus + 5.5 mg/dL, p = 0.01) with respect to the CG. Conclusions: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.
Original languageEnglish
JournalCancers
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2020

Keywords

  • *randomized controlled trial
  • *BRCA1/2 mutations
  • *insulin-like growth factor I
  • *mediterranean diet
  • *penetrance
  • *personalized medicine

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