A meningioma with islets of extramedullary myeloid metaplasia: Case report

Gianluigi Zona, Giannantonio Spena, Pier F. Sbaffi, Renato Spaziante

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: Idiopathic myelofibrosis is a clonal stem cell disorder that leads to ineffective erythropoiesis accompanied by reactive myelofibrosis (bone marrow fibrosis). As a consequence, extramedullary hematopoiesis characteristically develops. The central nervous system is rarely affected; the spinal canal and the cranial meninges are generally the preferred locations. Extramedullary hematopoiesis within central nervous system primary tumors have already been reported but, to our knowledge, never before in a patient with evidence of idiopathic myelofibrosis. CLINICAL PRESENTATION: A patient experiencing generalized idiopathic myelofibrosis developed a hemorrhagic intracranial meningioma containing islets of extramedullary myeloid metaplasia. INTERVENTION: The tumor was radically removed through a right frontal craniotomy. After surgery, the patient recovered completely and was discharged with a normal neurological status. After 6 years, the patient is in excellent condition with no sign of recurrence on magnetic resonance imaging scans. CONCLUSION: The reasons for this uncommon association are uncertain, but we hypothesize that myeloid islets may be involved in the origin of the tumor as well as in its acute hemorrhagic onset. Moreover, we suggest that in the presence of proven idiopathic myelofibrosis intracranial myeloid metaplasia should be ruled out by appropriate neuroimaging and considered as a potential diagnosis in the presence of brain lesions.

Original languageEnglish
JournalNeurosurgery
Volume61
Issue number2
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Primary Myelofibrosis
Meningioma
Extramedullary Hematopoiesis
Meninges
Central Nervous System Neoplasms
Spinal Canal
Craniotomy
Erythropoiesis
Neuroimaging
Neoplasms
Stem Cells
Central Nervous System
Magnetic Resonance Imaging
Recurrence
Brain

Keywords

  • Idiopathic myelofibrosis
  • Intracranial extramedullary hematopoieis
  • Meningioma
  • Myeloid metaplasia

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

A meningioma with islets of extramedullary myeloid metaplasia : Case report. / Zona, Gianluigi; Spena, Giannantonio; Sbaffi, Pier F.; Spaziante, Renato.

In: Neurosurgery, Vol. 61, No. 2, 08.2007.

Research output: Contribution to journalArticle

Zona, Gianluigi ; Spena, Giannantonio ; Sbaffi, Pier F. ; Spaziante, Renato. / A meningioma with islets of extramedullary myeloid metaplasia : Case report. In: Neurosurgery. 2007 ; Vol. 61, No. 2.
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