A meta-analysis of alcohol consumption and the risk of brain tumours

C. Galeone, S. Malerba, M. Rota, V. Bagnardi, E. Negri, L. Scotti, R. Bellocco, G. Corrao, P. Boffetta, C. La Vecchia, C. Pelucchi

Research output: Contribution to journalArticle


Background: Alcohol is capable of traversing the blood-brain barrier and is thus a possible risk factor for brain cancer. Several epidemiological studies have been published on the issue, a number of those during recent years, with inconsistent findings. Materials and methods: We performed a systematic literature search in the Medline and EMBASE databases. We found a total of 19 studies providing risk estimates for total alcohol or specific alcoholic beverages. Pooled estimates of the relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models. Results: The pooled RR of brain cancer for alcohol drinkers versus non-drinkers was 0.97 (95% CI 0.82-1.15; based on 12 studies). Moderate (

Original languageEnglish
Article numbermds432
Pages (from-to)514-523
Number of pages10
JournalAnnals of Oncology
Issue number2
Publication statusPublished - Feb 2013


  • Alcohol drinking
  • Brain neoplasms
  • Glioma
  • Meningioma
  • Meta-analysis
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Hematology

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    Galeone, C., Malerba, S., Rota, M., Bagnardi, V., Negri, E., Scotti, L., Bellocco, R., Corrao, G., Boffetta, P., La Vecchia, C., & Pelucchi, C. (2013). A meta-analysis of alcohol consumption and the risk of brain tumours. Annals of Oncology, 24(2), 514-523. [mds432]. https://doi.org/10.1093/annonc/mds432