A meta-analysis of alcohol drinking and cancer risk

V. Bagnardi, M. Blangiardo, C. La Vecchia, G. Corrao

Research output: Contribution to journalArticle

411 Citations (Scopus)

Abstract

To evaluate the strength of the evidence provided by the epidemiological literature on the association between alcohol consumption and the risk of 18 neoplasms, we performed a search of the epidemiological literature from 1966 to 2000 using several bibliographic databases. Meta-regression models were fitted considering linear and non-linear effects of alcohol intake. The effects of characteristics of the studies, of selected covariates (tobacco) and of the gender of individuals included in the studies, were also investigated as putative sources of heterogeneity of the estimates. A total of 235 studies including over 117 000 cases were considered. Strong trends in risk were observed for cancers of the oral cavity and pharynx, oesophagus and larynx. Less strong direct relations were observed for cancers of the stomach, colon and rectum, liver, breast and ovary. For all these diseases, significant increased risks were found also for ethanol intake of 25 g per day. No significant nor consistent relation was observed for cancers of the pancreas, lung, prostate or bladder. Allowance for tobacco appreciably modified the relations with laryngeal, lung and bladder cancers, but not those with oral, oesophageal or colorectal cancers. This meta-analysis showed no evidence of a threshold effect for most alcohol-related neoplasms. The inference is limited by absence of distinction between lifelong abstainers and former drinkers in several studies, and the possible selective inclusion of relevant sites only in cohort studies.

Original languageEnglish
Pages (from-to)1700-1705
Number of pages6
JournalBritish Journal of Cancer
Volume85
Issue number11
DOIs
Publication statusPublished - Nov 30 2001

Fingerprint

Alcohol Drinking
Meta-Analysis
Mouth Neoplasms
Tobacco
Lung Neoplasms
Alcohols
Pharyngeal Neoplasms
Bibliographic Databases
Neoplasms
Laryngeal Neoplasms
Esophageal Neoplasms
Rectal Neoplasms
Larynx
Pancreatic Neoplasms
Urinary Bladder Neoplasms
Colonic Neoplasms
Esophagus
Stomach Neoplasms
Mouth
Prostate

Keywords

  • Alcohol intake
  • Humans
  • Meta-analysis
  • Neoplasms
  • Risk

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A meta-analysis of alcohol drinking and cancer risk. / Bagnardi, V.; Blangiardo, M.; Vecchia, C. La; Corrao, G.

In: British Journal of Cancer, Vol. 85, No. 11, 30.11.2001, p. 1700-1705.

Research output: Contribution to journalArticle

Bagnardi, V, Blangiardo, M, Vecchia, CL & Corrao, G 2001, 'A meta-analysis of alcohol drinking and cancer risk', British Journal of Cancer, vol. 85, no. 11, pp. 1700-1705. https://doi.org/10.1054/bjoc.2001.2140
Bagnardi, V. ; Blangiardo, M. ; Vecchia, C. La ; Corrao, G. / A meta-analysis of alcohol drinking and cancer risk. In: British Journal of Cancer. 2001 ; Vol. 85, No. 11. pp. 1700-1705.
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