A meta-analysis of alcohol drinking and oral and pharyngeal cancers

Results from subgroup analyses

F. Turati, W. Garavello, I. Tramacere, C. Pelucchi, C. Galeone, V. Bagnardi, G. Corrao, F. Islami, V. Fedirko, P. Boffetta, C. La Vecchia, E. Negri

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

To quantify the magnitude of the association between alcohol and oral and pharyngeal cancer (OPC) by sex,smoking habits, type of alcoholic beverage and other factors. Methods: We combined findings from all case-control and cohort studies published until September 2010 and present in this article the results classified by these factors, using a meta- nalytic approach.Summary relative risks (RRs) were obtained using random-effects models; heterogeneity was assessed using the X2 test. Results: The association between alcohol and OPC risk was similar in men and women, with similar dose-response relationships.No notable differences were found with respect to geographic area and other factors, both for drinking overall and heavy (≥4 drinks/day) drinking. Among never/non-current smokers, the pooled RRs were 1.32 (95% confidence interval, CI, 1.05-1.67) for drinking,and 2.54 (95% CI, 1.80-3.58) for heavy drinking. The corresponding RRs in smokers were 2.92 (95% CI, 2.31-3.70) and 6.32(95% CI, 5.05-7.90). The pooled RRs for any drinking irrespective of smoking were 2.12 (95% CI, 1.37-3.29) for wine-, 2.43 (95%CI, 1.92-3.07) for beer- and 2.30 (95% CI, 1.78-2.98) for spirits-only drinking. The corresponding RRs for heavy drinking were 4.92 (95% CI, 2.80-8.65), 4.20 (95% CI, 1.43-12.38) and 5.20 (95% CI, 2.77-9.78). Conclusion: The alcohol-related RRs are similar with respect to sex, geographic area and type of alcoholic beverage. The association between alcohol and OPC is stronger in smokers than in non-smokers.

Original languageEnglish
Article numberags100
Pages (from-to)107-118
Number of pages12
JournalAlcohol and Alcoholism
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Pharyngeal Neoplasms
Mouth Neoplasms
Alcohol Drinking
Drinking
Meta-Analysis
Alcohols
Alcoholic Beverages
Smoking
Beer
Wine
Habits
Case-Control Studies
Cohort Studies
Confidence Intervals

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

A meta-analysis of alcohol drinking and oral and pharyngeal cancers : Results from subgroup analyses. / Turati, F.; Garavello, W.; Tramacere, I.; Pelucchi, C.; Galeone, C.; Bagnardi, V.; Corrao, G.; Islami, F.; Fedirko, V.; Boffetta, P.; La Vecchia, C.; Negri, E.

In: Alcohol and Alcoholism, Vol. 48, No. 1, ags100, 01.2013, p. 107-118.

Research output: Contribution to journalArticle

Turati, F, Garavello, W, Tramacere, I, Pelucchi, C, Galeone, C, Bagnardi, V, Corrao, G, Islami, F, Fedirko, V, Boffetta, P, La Vecchia, C & Negri, E 2013, 'A meta-analysis of alcohol drinking and oral and pharyngeal cancers: Results from subgroup analyses', Alcohol and Alcoholism, vol. 48, no. 1, ags100, pp. 107-118. https://doi.org/10.1093/alcalc/ags100
Turati, F. ; Garavello, W. ; Tramacere, I. ; Pelucchi, C. ; Galeone, C. ; Bagnardi, V. ; Corrao, G. ; Islami, F. ; Fedirko, V. ; Boffetta, P. ; La Vecchia, C. ; Negri, E. / A meta-analysis of alcohol drinking and oral and pharyngeal cancers : Results from subgroup analyses. In: Alcohol and Alcoholism. 2013 ; Vol. 48, No. 1. pp. 107-118.
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abstract = "To quantify the magnitude of the association between alcohol and oral and pharyngeal cancer (OPC) by sex,smoking habits, type of alcoholic beverage and other factors. Methods: We combined findings from all case-control and cohort studies published until September 2010 and present in this article the results classified by these factors, using a meta- nalytic approach.Summary relative risks (RRs) were obtained using random-effects models; heterogeneity was assessed using the X2 test. Results: The association between alcohol and OPC risk was similar in men and women, with similar dose-response relationships.No notable differences were found with respect to geographic area and other factors, both for drinking overall and heavy (≥4 drinks/day) drinking. Among never/non-current smokers, the pooled RRs were 1.32 (95{\%} confidence interval, CI, 1.05-1.67) for drinking,and 2.54 (95{\%} CI, 1.80-3.58) for heavy drinking. The corresponding RRs in smokers were 2.92 (95{\%} CI, 2.31-3.70) and 6.32(95{\%} CI, 5.05-7.90). The pooled RRs for any drinking irrespective of smoking were 2.12 (95{\%} CI, 1.37-3.29) for wine-, 2.43 (95{\%}CI, 1.92-3.07) for beer- and 2.30 (95{\%} CI, 1.78-2.98) for spirits-only drinking. The corresponding RRs for heavy drinking were 4.92 (95{\%} CI, 2.80-8.65), 4.20 (95{\%} CI, 1.43-12.38) and 5.20 (95{\%} CI, 2.77-9.78). Conclusion: The alcohol-related RRs are similar with respect to sex, geographic area and type of alcoholic beverage. The association between alcohol and OPC is stronger in smokers than in non-smokers.",
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AU - Turati, F.

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AU - Tramacere, I.

AU - Pelucchi, C.

AU - Galeone, C.

AU - Bagnardi, V.

AU - Corrao, G.

AU - Islami, F.

AU - Fedirko, V.

AU - Boffetta, P.

AU - La Vecchia, C.

AU - Negri, E.

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N2 - To quantify the magnitude of the association between alcohol and oral and pharyngeal cancer (OPC) by sex,smoking habits, type of alcoholic beverage and other factors. Methods: We combined findings from all case-control and cohort studies published until September 2010 and present in this article the results classified by these factors, using a meta- nalytic approach.Summary relative risks (RRs) were obtained using random-effects models; heterogeneity was assessed using the X2 test. Results: The association between alcohol and OPC risk was similar in men and women, with similar dose-response relationships.No notable differences were found with respect to geographic area and other factors, both for drinking overall and heavy (≥4 drinks/day) drinking. Among never/non-current smokers, the pooled RRs were 1.32 (95% confidence interval, CI, 1.05-1.67) for drinking,and 2.54 (95% CI, 1.80-3.58) for heavy drinking. The corresponding RRs in smokers were 2.92 (95% CI, 2.31-3.70) and 6.32(95% CI, 5.05-7.90). The pooled RRs for any drinking irrespective of smoking were 2.12 (95% CI, 1.37-3.29) for wine-, 2.43 (95%CI, 1.92-3.07) for beer- and 2.30 (95% CI, 1.78-2.98) for spirits-only drinking. The corresponding RRs for heavy drinking were 4.92 (95% CI, 2.80-8.65), 4.20 (95% CI, 1.43-12.38) and 5.20 (95% CI, 2.77-9.78). Conclusion: The alcohol-related RRs are similar with respect to sex, geographic area and type of alcoholic beverage. The association between alcohol and OPC is stronger in smokers than in non-smokers.

AB - To quantify the magnitude of the association between alcohol and oral and pharyngeal cancer (OPC) by sex,smoking habits, type of alcoholic beverage and other factors. Methods: We combined findings from all case-control and cohort studies published until September 2010 and present in this article the results classified by these factors, using a meta- nalytic approach.Summary relative risks (RRs) were obtained using random-effects models; heterogeneity was assessed using the X2 test. Results: The association between alcohol and OPC risk was similar in men and women, with similar dose-response relationships.No notable differences were found with respect to geographic area and other factors, both for drinking overall and heavy (≥4 drinks/day) drinking. Among never/non-current smokers, the pooled RRs were 1.32 (95% confidence interval, CI, 1.05-1.67) for drinking,and 2.54 (95% CI, 1.80-3.58) for heavy drinking. The corresponding RRs in smokers were 2.92 (95% CI, 2.31-3.70) and 6.32(95% CI, 5.05-7.90). The pooled RRs for any drinking irrespective of smoking were 2.12 (95% CI, 1.37-3.29) for wine-, 2.43 (95%CI, 1.92-3.07) for beer- and 2.30 (95% CI, 1.78-2.98) for spirits-only drinking. The corresponding RRs for heavy drinking were 4.92 (95% CI, 2.80-8.65), 4.20 (95% CI, 1.43-12.38) and 5.20 (95% CI, 2.77-9.78). Conclusion: The alcohol-related RRs are similar with respect to sex, geographic area and type of alcoholic beverage. The association between alcohol and OPC is stronger in smokers than in non-smokers.

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