TY - JOUR
T1 - A meta-analysis of nevus-associated melanoma
T2 - Prevalence and practical implications
AU - Pampena, Riccardo
AU - Kyrgidis, Athanassios
AU - Lallas, Aimilios
AU - Moscarella, Elvira
AU - Argenziano, Giuseppe
AU - Longo, Caterina
PY - 2017
Y1 - 2017
N2 - The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I2 = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39 mm; 95% CI -0.60 to -0.18; P = .0003; I2 = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P = .24; I2 = 98%).
AB - The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I2 = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39 mm; 95% CI -0.60 to -0.18; P = .0003; I2 = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P = .24; I2 = 98%).
KW - Dysplastic nevus
KW - Melanoma
KW - Meta-analysis
KW - Nevus-associated
KW - Prevalence
KW - Thickness
UR - http://www.scopus.com/inward/record.url?scp=85028455711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028455711&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2017.06.149
DO - 10.1016/j.jaad.2017.06.149
M3 - Article
AN - SCOPUS:85028455711
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
ER -