A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk

I. Tramacere, C. Pelucchi, V. Bagnardi, M. Rota, L. Scotti, F. Islami, G. Corrao, P. Boffetta, C. La vecchia, E. Negri

Research output: Contribution to journalArticle

Abstract

Background: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. Patients and methods: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. Results: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤1 drink per day), 0.90 for moderate (1 to

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalAnnals of Oncology
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Alcohol drinking
  • Dose-risk relation
  • Esophageal and gastric cardia adenocarcinomas
  • Meta-analysis
  • Systematic review

ASJC Scopus subject areas

  • Oncology
  • Hematology

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    Tramacere, I., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., Islami, F., Corrao, G., Boffetta, P., La vecchia, C., & Negri, E. (2012). A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Annals of Oncology, 23(2), 287-297. https://doi.org/10.1093/annonc/mdr136