A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma

Irene Tramacere, Claudio Pelucchi, Martina Bonifazi, Vincenzo Bagnardi, Matteo Rota, Rino Bellocco, Lorenza Scotti, Farhad Islami, Giovanni Corrao, Paolo Boffetta, Carlo La Vecchia, Eva Negri

Research output: Contribution to journalArticle

Abstract

The role of alcohol intake in the risk of Hodgkin lymphoma (HL) is still largely unclear. To summarize the evidence on the issue, we carried out a meta-analysis of the available studies. We identified eight case-control and two cohort studies, including a total of 1488 cases of HL. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and carried out a dose-risk analysis using nonlinear random-effects metaregression models. Compared with nondrinkers, the relative risk for alcohol consumers was 0.70 [95% confidence interval (CI), 0.60-0.81] overall, 0.66 (95% CI, 0.56-0.78) among case-control, and 0.92 (95% CI, 0.63-1.33) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.71 (95% CI, 0.57-0.89) for light (i.e. ≤1 drink/day) and 0.73 (95% CI, 0.60-0.87) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinking. This meta-analysis suggests a favourable effect of alcohol on HL, in the absence, however, of a dose-risk relationship. The inverse association was restricted to - or greater in - case-control as compared with cohort studies. This indicates caution in the interpretation of results.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume21
Issue number3
DOIs
Publication statusPublished - May 2012

Keywords

  • alcohol drinking
  • dose-risk relation
  • Hodgkin lymphoma
  • meta-analysis
  • systematic review

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

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  • Cite this

    Tramacere, I., Pelucchi, C., Bonifazi, M., Bagnardi, V., Rota, M., Bellocco, R., Scotti, L., Islami, F., Corrao, G., Boffetta, P., La Vecchia, C., & Negri, E. (2012). A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma. European Journal of Cancer Prevention, 21(3), 268-273. https://doi.org/10.1097/CEJ.0b013e328350b11b