A method for assessing catheter patency in implanted pumps for long-term intraperitoneal insulin delivery

Marina Scavini, Bjorn Hammarberg, Flaviano Dosio, Michiela Torri, Giovanna Petrella, Gabriella Galimberti, Silvia Vai, Ferruccio Fazio, Guido Pozza

Research output: Contribution to journalArticlepeer-review

Abstract

Catheter complications are a common problem during long-term insulin therapy with implanted pumps. The purpose of this study was to test the feasibility of imaging intraperitoneal catheters with technetium (Tc) 99m in implantable devices for insulin delivery. Testing physical stability of an insulin/Tc 99 mixture did not show formation of insulin aggregates during a period up to 48 h on a rotating wheel. Five hundred microCurie (equal to 18 MBq) of Tc 99m were injected in the flush port of a pump or intraperitoneal insulin delivery implanted in patients with type 1 (insulin dependent) diabetes mellitus, and gamma camera images were obtained for 30 min. In patent catheters the tracer rapidly imaged the whole length of the catheter while in occluded catheters the tracer remained in the flushport, imaging only the portion of the catheter before the occlusion. In patent catheters in which insulin absorption was impaired, the tracer rapidly imaged the whole length of the catheter, but its removal from the peritoneum was delayed. Tc 99m imaging of intraperitoneal catheters for insulin delivery can be used to assess catheter patency and impaired delivery into the peritoneal cavity.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalArtificial Organs
Volume21
Issue number5
Publication statusPublished - 1997

Keywords

  • implantable insulin pumps
  • intraperitoneal insulin delivery
  • Technetium 99m imaging

ASJC Scopus subject areas

  • Biophysics

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