A method for dynamic subtraction MR imaging of the liver

Luca T. Mainardi, Katia M. Passera, Agnese Lucesoli, Paolo Potepan, Ernesto Setti, Renato Musumeci

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Subtraction of Dynamic Contrast-Enhanced 3D Magnetic Resonance (DCE-MR) volumes can result in images that depict and accurately characterize a variety of liver lesions. However, the diagnostic utility of subtraction images depends on the extent of co-registration between non-enhanced and enhanced volumes. Movement of liver structures during acquisition must be corrected prior to subtraction. Currently available methods are computer intensive. We report a new method for the dynamic subtraction of MR liver images that does not require excessive computer time. Methods: Nineteen consecutive patients (median age 45 years; range 37-67) were evaluated by VIBE TI-weighted sequences (TR 5.2 ms, TE 2.6 ms, flip angle 20°, slice thickness 1.5 mm) acquired before and 45s after contrast injection. Acquisition parameters were optimized for best portal system enhancement. Pre and post-contrast liver volumes were realigned using our 3D registration method which combines: (a) rigid 3D translation using maximization of normalized mutual information (NMI), and (b) fast 2D non-rigid registration which employs a complex discrete wavelet transform algorithm to maximize pixel phase correlation and perform multiresolution analysis. Registration performance was assessed quantitatively by NMI. Results: The new registration procedure was able to realign liver structures in all 19 patients. NMI increased by about 8% after rigid registration (native vs. rigid registration 0.073 ± 0.031 vs. 0.078 ± 0.031, n.s., paired t-test) and by a further 23% (0.096 ± 0.035 vs. 0.078 ± 0.031, p <0.001, paired t-test) after non-rigid realignment. The overall average NMI increase was 31%. Conclusion: This new method for realigning dynamic contrast-enhanced 3D MR volumes of liver leads to subtraction images that enhance diagnostic possibilities for liver lesions.

Original languageEnglish
Article number5
JournalBMC Medical Imaging
Volume6
DOIs
Publication statusPublished - Jun 7 2006

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Liver
Portal System
Wavelet Analysis
Magnetic Resonance Spectroscopy
Injections

ASJC Scopus subject areas

  • Medicine(all)

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Mainardi, L. T., Passera, K. M., Lucesoli, A., Potepan, P., Setti, E., & Musumeci, R. (2006). A method for dynamic subtraction MR imaging of the liver. BMC Medical Imaging, 6, [5]. https://doi.org/10.1186/1471-2342-6-5

A method for dynamic subtraction MR imaging of the liver. / Mainardi, Luca T.; Passera, Katia M.; Lucesoli, Agnese; Potepan, Paolo; Setti, Ernesto; Musumeci, Renato.

In: BMC Medical Imaging, Vol. 6, 5, 07.06.2006.

Research output: Contribution to journalArticle

Mainardi, LT, Passera, KM, Lucesoli, A, Potepan, P, Setti, E & Musumeci, R 2006, 'A method for dynamic subtraction MR imaging of the liver', BMC Medical Imaging, vol. 6, 5. https://doi.org/10.1186/1471-2342-6-5
Mainardi, Luca T. ; Passera, Katia M. ; Lucesoli, Agnese ; Potepan, Paolo ; Setti, Ernesto ; Musumeci, Renato. / A method for dynamic subtraction MR imaging of the liver. In: BMC Medical Imaging. 2006 ; Vol. 6.
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