A method for morphological characterization of dural ectasia in Marfan syndrome

Maria I. Iacono, Katia Passera, Lorenzo Magrassi, Roberto Dore, Paolo Lago, Eloisa Arbustini, Luca T. Mainardi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we reported a novel method to detect and quantify dural ectasia in Marfan syndrome. Firstly, the dural sacs of 8 Marfan patients were segmented by applying an unsupervised Fuzzy C-Means method on T2-weighed magnetic resonance images. Then, for each patient a tubular model of the dural sac was extracted by detecting and removing the existent pathological extrusions. The segmented images together with the resulting tube were then rendered using a marching cubes algorithm. The proposed algorithm represents a first attempt to quantify and to morphologically characterize the pathological ectasia that usually accompanies the Marfan disorder. The generated 3D reconstruction and the opportunity to overlap them with a physiological model provides the clinician with a tool for a panoramic view of the structures and a means for a more accurate inspection of ectasia. In addition the extracted parameters furnish quantitative and reproducible measures that could be useful as discriminative indexes for an automatic and more objective diagnosis.

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages5764-5767
Number of pages4
DOIs
Publication statusPublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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  • Cite this

    Iacono, M. I., Passera, K., Magrassi, L., Dore, R., Lago, P., Arbustini, E., & Mainardi, L. T. (2009). A method for morphological characterization of dural ectasia in Marfan syndrome. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 5764-5767). [5332525] https://doi.org/10.1109/IEMBS.2009.5332525