A method for the determination of imipramine in human plasma by gas-liquid chromatography-mass fragmentography

A. Frigerio, G. Belvedere, F. De Nadai, R. Fanelli, C. Pantarotto, E. Riva, P. L. Morselli

Research output: Contribution to journalArticle

Abstract

A sensitive and specific method for the quantitative determination of imipramine in human biological fluids is described. After extraction with n-hexane, imipramine is detected by gas-liquid chromatography-mass fragmentography. The procedure permits routine analysis on relatively small amounts of plasma (1-2 ml) containing as little as 10 ng/ml of imipramine without any interference from endogenous substrates.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalJournal of Chromatography A
Volume74
Issue number2
DOIs
Publication statusPublished - Dec 20 1972

ASJC Scopus subject areas

  • Analytical Chemistry

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  • Cite this

    Frigerio, A., Belvedere, G., De Nadai, F., Fanelli, R., Pantarotto, C., Riva, E., & Morselli, P. L. (1972). A method for the determination of imipramine in human plasma by gas-liquid chromatography-mass fragmentography. Journal of Chromatography A, 74(2), 201-208. https://doi.org/10.1016/S0021-9673(01)86150-1