A sensitive and specific method for the quantitative determination of imipramine in human biological fluids is described. After extraction with n-hexane, imipramine is detected by gas-liquid chromatography-mass fragmentography. The procedure permits routine analysis on relatively small amounts of plasma (1-2 ml) containing as little as 10 ng/ml of imipramine without any interference from endogenous substrates.
ASJC Scopus subject areas
- Analytical Chemistry