Abstract
In recent years MSCs have become a very attractive tool in tissue engineering and regenerative medicine because of their ability to be committed along several lineages through chemical or physical stimuli. Nevertheless their therapeutic potential and plasticity are not yet totally understood. This report describes the use of AFM together with conventional microscopies to obtain mechanical information on cell surfaces and deposited extra cellular matrix molecules, after inducing the differentiation of human MSCs towards three typical mesoderm phenotypes. The aim is to correlate morphological, functional, and mechanical aspects of human MSCs to obtain a deeper understanding of their great potential. (Graph Presented).
| Original language | English |
|---|---|
| Pages (from-to) | 589-598 |
| Number of pages | 10 |
| Journal | Macromolecular Bioscience |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 10 2007 |
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Keywords
- Atomic force microscopy (AFM)
- Cell topography
- Differentiation
- Human mesenchymal stem cells (hMSC)
- Imaging
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Bioengineering
- Biomaterials
- Materials Chemistry
- Polymers and Plastics
Cite this
A micro/nanoscale surface mechanical study on morpho-functional changes in multilineage-differentiated human mesenchymal stem cells. / Danti, Serena; D'Acunto, Mario; Trombi, Luisa; Berrettini, Stefano; Pietrabissa, Andrea.
In: Macromolecular Bioscience, Vol. 7, No. 5, 10.05.2007, p. 589-598.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A micro/nanoscale surface mechanical study on morpho-functional changes in multilineage-differentiated human mesenchymal stem cells
AU - Danti, Serena
AU - D'Acunto, Mario
AU - Trombi, Luisa
AU - Berrettini, Stefano
AU - Pietrabissa, Andrea
PY - 2007/5/10
Y1 - 2007/5/10
N2 - In recent years MSCs have become a very attractive tool in tissue engineering and regenerative medicine because of their ability to be committed along several lineages through chemical or physical stimuli. Nevertheless their therapeutic potential and plasticity are not yet totally understood. This report describes the use of AFM together with conventional microscopies to obtain mechanical information on cell surfaces and deposited extra cellular matrix molecules, after inducing the differentiation of human MSCs towards three typical mesoderm phenotypes. The aim is to correlate morphological, functional, and mechanical aspects of human MSCs to obtain a deeper understanding of their great potential. (Graph Presented).
AB - In recent years MSCs have become a very attractive tool in tissue engineering and regenerative medicine because of their ability to be committed along several lineages through chemical or physical stimuli. Nevertheless their therapeutic potential and plasticity are not yet totally understood. This report describes the use of AFM together with conventional microscopies to obtain mechanical information on cell surfaces and deposited extra cellular matrix molecules, after inducing the differentiation of human MSCs towards three typical mesoderm phenotypes. The aim is to correlate morphological, functional, and mechanical aspects of human MSCs to obtain a deeper understanding of their great potential. (Graph Presented).
KW - Atomic force microscopy (AFM)
KW - Cell topography
KW - Differentiation
KW - Human mesenchymal stem cells (hMSC)
KW - Imaging
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UR - http://www.scopus.com/inward/citedby.url?scp=34547962432&partnerID=8YFLogxK
U2 - 10.1002/mabi.200600271
DO - 10.1002/mabi.200600271
M3 - Article
VL - 7
SP - 589
EP - 598
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
IS - 5
ER -