A micro/nanoscale surface mechanical study on morpho-functional changes in multilineage-differentiated human mesenchymal stem cells

Serena Danti, Mario D'Acunto, Luisa Trombi, Stefano Berrettini, Andrea Pietrabissa

Research output: Contribution to journalArticle

Abstract

In recent years MSCs have become a very attractive tool in tissue engineering and regenerative medicine because of their ability to be committed along several lineages through chemical or physical stimuli. Nevertheless their therapeutic potential and plasticity are not yet totally understood. This report describes the use of AFM together with conventional microscopies to obtain mechanical information on cell surfaces and deposited extra cellular matrix molecules, after inducing the differentiation of human MSCs towards three typical mesoderm phenotypes. The aim is to correlate morphological, functional, and mechanical aspects of human MSCs to obtain a deeper understanding of their great potential. (Graph Presented).

Original languageEnglish
Pages (from-to)589-598
Number of pages10
JournalMacromolecular Bioscience
Volume7
Issue number5
DOIs
Publication statusPublished - May 10 2007

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Keywords

  • Atomic force microscopy (AFM)
  • Cell topography
  • Differentiation
  • Human mesenchymal stem cells (hMSC)
  • Imaging

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Bioengineering
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

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